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|本期目录/Table of Contents|

MiRNA-137在急性冠脉综合征患者中表达及其临床意义

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第5期
页码:
520-523
栏目:
临床研究
出版日期:
2018-06-25

文章信息/Info

Title:
MiRNA-137 expression and its clinical significance in patients with acute coronary syndrome
作者:
李巍; 胡朗; 赵青; 邱继欢; 亓秉超; 尹志勇; 李妍
（第四军医大学西京医院心血管内科，陕西 西安 710032）
Author(s):
LI Wei;  HU Lang;  ZHAO Qing;  QIU Ji-huan;  QI Bing-chao;  YIN Zhi-yong;  LI Yan
(Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
急性冠脉综合征; 小核糖核酸-137
Keywords:
acute coronary syndrome;  MiRNA-137
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨小核糖核酸（miRNA）-137在急性冠脉综合征（ACS）患者及冠状动脉无病变者血浆中含量的差异及其临床意义。方法 采集ACS患者(68例)及冠状动脉无病变者(非冠心病组，32例)的血浆，提取总miRNA，运用荧光实时定量PCR(qRT-PCR)方法检测miRNA-137含量及分析miRNA-137在各组中的差异表达。测定肌酸激酶同功酶（CK-MB）、心肌肌钙蛋白（cTn）I、脑钠尿肽（BNP）、冠脉SYNTAX积分和左室射血分数（LVEF） 值等，并分析miRNA-137与这些临床指标的相关性。结果 与非冠心病组比较，ACS患者miRNA-137表达差异有统计学意义(P<0.05)，多因素Logistic回归分析表明miRNA-137是ACS的独立相关因素（P<0.01）；相关分析表明:ACS患者循环miRNA-137的表达量与BNP、cTnI呈正相关。而在冠脉病变血管数目不同组间，miRNA-137表达并无明显统计学差异。另外,miRNA-137表达量在不同SYNTAX评分组之间不全相同，差异有统计学意义。结论 miRNA-137是ACS的独立相关因素，可部分反映ACS患者的严重程度，可能成为ACS潜在的诊断学标记物。
Abstract:
AIM To investigate the different expression and clinical significance of miRNA-137 between patients with acute coronary syndrome and subjects without coronary artery lesions. METHODS Collection of plasma of ACS patients (Non-CHD, n=68) and subjects without coronary artery lesions (n=32) was performed. The plasma miRNA-137 expression was tested by qRT-PCR. Differential expression was analyzed statistically. Analysis of correlation between miRNA-137 and the measured data, including CK-MB, cTnI,BNP, SYNTAX score and LVEF. RESULTS miRNA-137 of ACS was significant higher than that of the Non-CHD group (P<0.05); Multivariate logistic regression analysis showed that miRNA-137 was an independent related factor of ACS (P<0.01); Correlation analysis showed that miRNA-137 was positively associated with BNP and cTnI.There were no statistical differences among the different vessel groups of miRNA-137. In addition, not all of the groups of SYNTAX score had the same expression of miRNA-137. CONCLUSION The miRNA-137 is an independent related factor of ACS which may be used to reflect severity of ACS. Additionally, it may be a potential biomarker of ACS.

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备注/Memo

备注/Memo:
收稿日期：2017-12-15.通讯作者：李妍，副教授，主要从事复杂冠心病诊治研究Email：xijingliyan@163.com 共同通讯作者：尹志勇，讲师，博士，主要从事缺血性心脏病损伤与保护研究 Email：zhiyong_yin@163.com 作者简介：李巍，住院医师，硕士生 Email：364573149@qq.com
更新日期/Last Update: 1900-01-01