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降钙素基因相关肽对心肌缺血时心脏功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1996年第3期
页码:
140-144
栏目:
论著
出版日期:
1996-05-01

文章信息/Info

Title:
Effects of calcitonin gene-related peptide on cardiac function
作者:
裴建明1　李红梅2　牛国保1　朱妙章1　臧益民1 王跃民1　张宁仔3　施溥涛4　蓝　中
第四军医大学　1生理学教研室　西安　710032　2解放军第323 医院心脏内科　3唐都医院心脏内科　4上海生化研究所
Author(s):
Pei Jianming1;  Li Hongmei2;  Niu Guobao1;  Zhu Miaozhang1;  Zang Yimin1;  Wang Yaomin1;  Zhang Ningzi3;  Shi Futao4;  Lan Zhong
1Department of Physiology, Forth Military Medical University, Xi′an 710032 2Department of Cardiac Internal Medicine, Hospital 323 of PLA , Xi′an 3Department of Cardiac Internal Medicine, Tangdu Haspital 4Biochemistry Institue of Shanghai
关键词:
冠状动脉狭窄;  降钙素基因相关肽;  心脏功能
Keywords:
coronary stenosis;  calcitonin gene-related pept de;  heart function
分类号:
-
DOI:
-
文献标识码:
-
摘要:
冠脉内注射降钙素基因相关肽(CGRP) 0.3ug/kg, 对正常及不同程度冠脉狭窄犬的心功能产生不同影响。结果表明, 正常犬冠脉内注射CGRP 后, 平均动脉压(MAP) 下降1.2 kPa (P<0.05) , 同时,心率(HR)、心输出量(CO)、左室收缩压峰值(LVSP) 均不同程度增加; 左室舒张末压(LVEDP) 轻度降低。在中度狭窄30 min 后冠脉内注射CGRP 对HR、MAP 无明显影响; 而重度狭窄后注射CGRP, MAP 由狭窄时降低逐渐增高, HR 由增快而变慢。CO、LV SP 均显著增高, LVEDP 降低, 此作用较冠脉狭窄前更为明显。提示CGRP 能扩张冠状动脉, 增加冠脉血流量和心排血量, 增强心肌收缩力, 对缺血心脏功能有保护作用。
Abstract:
Different effects of intracoronary infusion of calcitonin gene-related peptide(CGRP) on cardiac function of normal and graded coronary stenotic dogs were observed.The results showed that the mean artery pressure (MAP) and the left ventricular end diastolic pressure(LVEDP) decreased (P<0.05) , the heart rate (HR) , cardiac output (CO)and left ventricular systolic pressure(LVSP)increased to varying degrees.But MAP and HR had no changes when CGRP was given intracoronary at 30min following middle coronary stenosis. After 30 min severe coronary stenosis, MAP elevated, HR slowed gradually and CO , LVSP increased, but LVEDP decreased. The above mentioned results suggested that CGRP has protect ive effects on ischemic myocardial function through increase of coronary blood flow and positive inotropic effect.

参考文献/References

［1］Rosenfeld MG,Amara SG.M ermod JJ,et al.Production of a novel neuropeptide encede by the calcitonin gene via tissuespecific RNA processing. Nature 1983; 304: 129.

［2］ Skofitsch G, Jacobowitr DM.Quantitative distribution of calcitonin gene-related peptide in ratcentral nervous system.Peptides 1985; 6: 1069.

［3］Mulderry PK, Ghatcl MA , Rodrigo J , et al.Calcitonin gene-related peptide in cardiovascular tissues of the rat. Neuroscience 1985; 14: 9478.

［4］Lundberg JM , Franco-coroccda A , et al. Coexistance of substance P and calcitonin gene-related peptide-like immunoreactivity in sensory nerves in relation to cardiovascular and bronchoconstrictors effects of capsaicin.Eur J Pharm acol 1985; 108: 315.

［5］陈士良, 臧益民, 朱妙章, 等.冠状动脉狭窄对血流量的影响. 生理学报1989; 41 (4) : 91.

［6］Dippette DJ , Rivier J ,Morris R, et al. Systemic and regional hemodynamic effects of calcitonin gene-related peptide. H ypertension 1987; 9: 142.

［7］Franco-Cerecede A , Gcnnari C, et al.Cardiovascular effects of calcitonin gene-related peptideⅠand Ⅱ in man.Circ Res 1987; 60: 393.

［8］韩启德, 史凤鸾, 王宪, 等.降钙素基因相关肽对大鼠冠状动脉结扎前后的血液动力学作用.北京医科大学学报1988; 20: 333.

［9］李红梅, 裴建明, 朱妙章, 等.降钙素基因相关肽对定量冠脉狭窄后血液动力学的作用中国病理生理杂志1993; 9: 581.

备注/Memo

备注/Memo:
Received 1995-06-01
更新日期/Last Update: 1996-05-01