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|本期目录/Table of Contents|

大豆磷脂对缺血再灌注家兔左室功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1996年第4期
页码:
203-206
栏目:
论著
出版日期:
1996-08-01

文章信息/Info

Title:
Effects of soybean phospholipid on left ventricular function in ischemia-reperfused rabbit
作者:
汪长华　余万桂　万绍华　张道明　晏年春
湖北省卫生职工医学院生理学教研室　荆沙 434000
Author(s):
Wang changhua;  Yu Wangui;  Wan Shaohua;  Zhang Daoming ;  Yan Nianchun
Department of Physiology, Hubei Health-Staff Medical College, Jingsha434000
关键词:
大豆磷脂;  再灌流损伤;  心室功能;  左
Keywords:
soybean phospholipid;  ventricular function;  left;  reperfusion injury
分类号:
-
DOI:
-
文献标识码:
-
摘要:
本文报道缺血再灌注时家兔左室功能的变化及大豆磷脂对它的影响。结果显示: 结扎冠脉左室支中点45 min、再灌注180 min 时, 左室收缩功能和舒张顺应性呈渐进性降低。在结扎前和再灌注即刻以脂质体形式补充大豆磷脂可减轻左室收缩和舒张功能的降低, 并可降低血浆乳酸脱氢酶活性。提示: 大豆磷脂对缺血再灌注时家兔左室功能的损伤具有保护作用。
Abstract:
This paper reports the effect of soybean phospholipid on the left ventricular function during ischemia-reperfusion in rabbits in vivo.The results showed that left ventricular systolic function and left ventricular diastolic compliance decreased progressively during 45 min of ischemia and 3 h of reperfusion.The supple of soybean phospholipid before ischemia and at the beginning of reperfusion could inhibit the decrease of left ventricular systolic function and left ventricular diastolic compliance and decrease the activity of LDH in plasma.The results indicated that soybean phospholipid has a protective effect of left ventricular function in ischemia reperfused rabbit.

参考文献/References

［1］时安云, 刘福安, 高子芬, 等.再灌注对实验性心肌梗塞家兔心功能的影响。病理生理学报1985; 1: 26.

［2］汪长华, 董传仁, 陈锡昌, 等.大豆磷脂脂质体对离体心肌细胞缺血-再灌注膜损伤的影响, 起搏与心脏1992; 6: 205.

［3］汪长华, 董传仁, 陈锡昌, 等.大豆磷脂脂质体对缺血-再灌注心肌细胞超微结构的影响, 起搏与心脏1993; 7: 205.

［4］Huang CH. Studies on phosphatidyloholine vesicles: Formation and physical characteristics.Biochemistry 1969; 8: 344.

［5］李其英, 徐勉忠, 孔祥云, 等.实用临床医学检验.武汉: 湖北人民出版社, 1980: 341～ 343.

［6］马文昭, 李肇特, 主编.磷脂类对于组织的作用.北京: 人民卫生出版社, 1963: 74～ 76.

［7］李芳生, 邹黎明, 段有金, 等.控制磷脂代谢对动物心肌细胞膜(膜结合酶) 的结构和功能的影响.生物化学与生物物理学报1984; 16: 694.

［8］van Bilsen M , van der Vusse GJ , Willemsen PHM , et al. Lipid alteration in isolated, working rat heart during ischemia and reperfusion: its relation to myocardial damage. Circ Res 1989;64 (2) : 304.

［9］Muller TM ,Marcus ML ,Mayer HE, et al. Liposime concentration in canine ischemic myocardium and depolarised myocardial cells. Circ Res 1981; 49 (2) : 405.

［10］Yechiel E, Barenholz Y. Relationships between membrane lipid composition and bilological p properties of rat myocytes: Effect of aging and manipulation of lipid composition. J Biol Chem 1985; 260 (16) : 9123.

备注/Memo

备注/Memo:
Received 1995-09-06
更新日期/Last Update: 1996-08-01