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|本期目录/Table of Contents|

家兔急性缺血性心力衰竭心机械功能动态变化特征及其对临床的启示(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1998年第1期
页码:
1-4
栏目:
论著
出版日期:
1998-01-01

文章信息/Info

Title:
Characteristics and significance of changes of cardiac mechanical function in acute ischemic heart failure of rabbits
作者:
侯应龙1　臧益民2　张宁仔1　王跃民2　朱妙章2　杜日映1
第四军医大学　1唐都医院心内科　2生理学教研室　西安 710032
Author(s):
Hou Yinglong1;  Zang Yimin2;  Zhang Ningzi1; Wang Yuemin2;  Zhu Miaozhang2; Du Riying1
1Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi′an 710038 2Department of Physiology, Fourth Military Medical University,Xi′an 710032
关键词:
心力衰竭　心功能　兔
Keywords:
heart failure　　cardiac function　　rabbit
分类号:
-
DOI:
-
文献标识码:
-
摘要:
为探讨急性缺血性心力衰竭(HF) 形成过程中心机械功能变化特征及其意义, 观察8只家兔, 于冠状动脉左室支结扎后, 不同时间点的左室收缩、舒张及射血功能的变化趋势, 并与7只假手术家兔比较。结果: 与假手术兔比较, HF兔于拮扎后5 min, 15 min, 30 min, 60 min, 120 min 和180 min, 左室内压上升最大速率分别降低:22.3% , 18.3% , 8.4% , 7.4% , 23.8% 和41.8% (均P<0.05) ; 左室收缩峰压分别降低: 23.8% (P<0.05) , 10.7%(P<0.05) , 6.4% , 6.9% , 13.9% (P<0.05) 和40.8% (P<0.05) ; 左室内压下降最大速率分别降低32.9% ,20.0% , 13.9% , 11.8% , 28.8% 和45.5% (均P<0.05) ; 左室舒张末压分别升高: 380.0% , 250.0% , 260.0% , 243.8% , 726.7% 和1450% (均P<0.05) ; 心输出量分别降低: 0.4% , 4.0% , 7.4% , 1214% (P<0.05) , 23.4% (P<0.05) 和36.9% (P<0.05)。结果表明, 心脏收缩与舒张功能于冠脉结扎后呈急剧下降2缓慢恢复2再继续下降的变化, 尤以舒张功能变化显著, 而射血功能呈逐渐减退。提示: ①冠脉闭塞早期应以改善心舒张功能为主, 并辅以保护收缩功能; ②临床心梗患者宜在心泵功能衰竭前尽早实施冠脉血运重建。
Abstract:
For the purpose of studying characteristics and significance of changes of cardiac mechan ical function in acute ischemic heart failure, the systolic, diastolic andejectional function of the heart in 8 rabbits were measured before and at different time points after ligating the left ventricular branch (LVB) of the coronary artery. The results were compared with those of rabbits that had undergone sham operation. It was shown that + dp/dtmax of rabbits with heart failure was decreased for 22.3%,18,3%,8.4%,7.4%,23.8% and 41.8% (all P< 0.05) at 5,15,30,60,120 and 180 min respectively after ligating LVB. LVSP for 23.8% (P<0.05),10.7% (P<0.05),6.4%,619%,13.9% (P<0.05) and 40.8% (P<0.05)respectively. -dp/dtmax for 32.9% ,20.0%,13.9%,11.8%,28.8%and45.5%(allP<0.05), respecyively. LVEDP was increased for 380.0%,250.0%,260.0%,243.8%,726.7% and 1450.0% (allP<0.05) , respectively. Cardiac output (CO) was decreased for 0.4%,4.0%,7.4%12.4% (P<0.05),23.4% (P<0.05) and 36.9% (P<0.05),respectively. The results indicated that cardiac systolic and diastolic function decreased sharply (in reducing period) after ligating LVB, then improved slowly (in compensative period),and reduced continueously (in failing period). Diastolic dysfuction was more remarkable,whereas ejectional function was gradually decreased. These results suggested that cardiac diastolic function should be mainly improved, and systolic function be protected in the early phase of obstruction of blood flow of the coronary artery. Meanwhile, revascularization for patients with aacute myocardial infarction should be performed as early as possible during compensative period of cardiac function.

参考文献/References

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［8］侯应龙.冠心病的二级预防.李景泰, 胡大一主编. 心血管病临床流行病学实践.第1 版.北京: 中国医药科技出版社, 1996; 74～103 .

备注/Memo

备注/Memo:
(收稿1997-04-04)
更新日期/Last Update: 1998-01-01