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|本期目录/Table of Contents|

急性心肌梗死溶栓治疗后心脏收缩功能的改善(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1998年第1期
页码:
15-16
栏目:
论著
出版日期:
1998-01-01

文章信息/Info

Title:
Improvement of cardiac contraction function in acute myocardial infarction treated by venous thrombolysis
作者:
顼志敏 王 雷 胡大一 崔 亮 吴雅峰 王红石 刘建章 刘晓惠
首都医科大学附属北京红十字朝阳医院心脏中心 北京 100020
Author(s):
Xu Zhimin; Wang Lei;  Hu Dayi;  Cui Liang ; Wu Yafeng ; Wang Hongshi;  Liu Jianzhang ;  Liu Xiaohui
Heart Center,Beijing Redcross Chaoyang Hospital, Capital Medical University,Beijing 100020
关键词:
心肌梗死;  急性　溶栓疗法　心脏功能;  收缩
Keywords:
myocardial infarction;  acute　thrombolytis therapy　cardiac function;  contraction
分类号:
-
DOI:
-
文献标识码:
-
摘要:
为观察急性心肌梗死(AMI) 患者, 静脉溶栓疗效与心脏收缩功能之关系。选88例接受静脉溶栓治疗的AM I患者, 分为两组: 溶栓再通组66例及未溶通组22例。以Killip分级判定临床心功能, 超声心动图测定左室射血分数(LVEF)。结果显示: ①重度左心功能不全(即Killip Ⅲ 级) 患者, 溶通组明显少于未溶通组(10.6% 比31.8% ) ; ②室壁瘤出现率, 溶通组明显少于未溶通组(9.1% 比36.4% ) ; ③LVEF值, 溶通组明显高于未溶通组(58.3±10.5 比50.9±11.9)。以上比较的P值均<0.01。可认为经静脉溶栓使梗死相关血管再灌注后的AMI患者, 左心室收缩功能一定程度上得以保护。
Abstract:
The objective of the present paper is to observe the relationship between the efficacy of venous thrombolytic therapy on aucte myocardial infarction (AMI) and cardiac function.Eighty-eight patients with AMI received venous thrombolytic therapy, and were divided into two groups: 66 cases of reperfusion and 22 no-reperfusion. The clinical cardiac function was judged by killipgrading, and the left ventricular ejection fraction (LVEF) were determined by echocardiogram. ①The cases of severe left heart dinsufficiency in reperfusion group were less than that in reperfusion group (10.6% vs 31.8% ). ②The rate of ventricular aneurysm was lower in group reperfusion than that in no-reperfusiongroup(9.1% vs 36.4% ,P<0.005). ③LVEF value was higher in reperfusion group than in no-reperfusion group (58.3±10.5 vs 50.9±11.9, P<0.01). The left cardiac function of contraction can be protected to certain extent for patients with AMI receiving venous thrombolytic therapy after the reperfusion of infarct related coronary artery.

参考文献/References

［1］Cairns JA,Fuster CV, Core J , et al. Coronary thrombolysis. Chest, 1995; 108 (4 Suppl):401s.

［2］链激酶多中心临床试验协作组. 急性心肌梗塞链激酶静脉溶栓疗法的多中心试验. 中华心血管病杂志, 1994;22: 403.

［3］Volpi A , Cavalli A , Santoro E, et al. Incidence and prognosis of secondary ventricular fibrillation in acute myocardial infarction: Evidence for a protective effect of thrombolytic therapy. Circulation, 1990; 82: 1279.

［4］The GUSTO Angiographic Investigators. The effects of tissue plasminogen activator, streptokinase, or both on coronary patency, ventricular function, and survival after acute myocardial infarction. N Engl J Med , 1993; 329:1615.

备注/Memo

备注/Memo:
(收稿1997-03-04)
更新日期/Last Update: 1998-01-01