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Title:: Evaluation of effects of 1, 6-FDP with nitroglycerin on heart failure

Author(s):: Wang Menghong ; Peng Jingtian; Luo Xiong ; Zhang Yanglong ; Deng Yuxiao; Zhang Zhiliang; First Affiliated Hospital of Jiangxi Medical College,Nanchang

Keywords:: 1; 6-fructose diphosphate　coronary heart disease　heart fialure 　treatment

摘要:: 为观察1,6-二磷酸果糖(FDP)与硝酸甘油合用治疗心力衰竭的疗效,以及对急性心肌梗死患者死亡率的影响, 选择病因不同的心力衰竭患者101例,分为2组.A组34例,单用硝酸甘油静脉滴注;B组67例,除静脉滴注硝酸甘油外, 还加用FDP 5 g 静脉点滴,每日2次,共7 d～10 d;对照组20例. 观察结果显示:A组、B组和对照组中冠心病心力衰竭患者心功能纠正显效率分别为40%(8/20) , 57% (12/21) 和10% (2/20),A组、B组与对照组比较, 差异有显著性(P<0.01),并以B组疗效最佳, 说明FDP与硝酸甘油合用能有效治疗冠心病心力衰竭。FDP对病因不同的心力衰竭患者的治疗, 则以冠心病心力衰竭患者疗效为佳。FDP可作为辅助药物治疗急性心肌梗死,但不能明显减少重症患者的死亡率。

Abstract:: Effects of 1,6-fructose diphosphate (1,6-FDP) with nitroglycerin on heart failure caused by various heart diseases and on acute myocardial infarction (AMI) mortality were evaluated. One hundred and one cases with heart failure due to various heart diseases were divided into two groups: Group A , 34 cases, treated with nitroglycerin only; Group B, 67 cases, with nitroglycerin and 1,6-FDP(5 g, iv,BID, 7～ 10 days). The control group was established with 20 cases. The rates of significant improvement of heart function in heart failure patient with coronary heart disease (CHD) were 40% (8/20) , 57% (12/21) and 10% (2/20) respectively in Group A , Group B and the control group. The rates of improvement were significantly higher in Group A and Group B than in the control group (P < 0.01) , and the rate of improvement in Group B was even higher than that in Group A. The results showed that the significant effects of 1, 6-FDP with nitroglycerin were produced on heart failure with CHD, 1,6-FDP was observed to be effective on heart failure and its effect was better on heart failure with CHD. But as the auxiliary drug, 1,6-FDP could not reduce the mortality of severe AMI patients.