我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

急性心肌梗死时心肌细胞凋亡的研究进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1999年第4期
页码:
254-256
栏目:
综述
出版日期:
1999-07-01

文章信息/Info

Title:
-
作者:
李忠真 综述　马　虹 审校
中山医科大学附属第一医院心内科,广州 510080
Author(s):
-
关键词:
心肌梗死;  急性　细胞凋亡
Keywords:
-
分类号:
-
DOI:
-
文献标识码:
-
摘要:
越来越多的研究表明急性心肌梗死(AMI)时,有两种心肌死亡形式: 凋亡和坏死。并且在急性心肌缺血6 h 内细胞凋亡是心肌细胞死亡的主要形式, 而心肌细胞坏死到1 d～2 d时才达高峰。进一步提示临床上争取早期恢复心肌再灌流, 抑制心肌细胞凋亡, 可减小梗死面积。细胞凋亡的调控机制是非常复杂的, 涉及多种基因、第二信使因子、细胞内酶活性等。本文作者着重介绍AMI时心肌细胞凋亡的研究现状及其调控机制的研究进展。
Abstract:
-

参考文献/References

［1］Bartling B, Hol J. Darmer D. Contribution ofmyocyte apoptosis to myocardial infarction. Basic Res Cardiol, 1998; 93 (2) : 71.

［2］Cheng W , Kajstura J ,Nitahara JA , et al. Programmed myocyte cell death affects the viable myocardium after infarction in rats. Exp Cell Res, 1996; 226: 316.

［3］Kerr JF,Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer, 1972; 26: 239.

［4］Shujen CH,Michael E,Bradley. Chemical hypoxia triffers apoptosis of cultured neonatal rat cardiac myocytes:Modulation by calciumregulated proteases and protein kinases. Mol Cell Biochem , 1998;178: 141.

［5］Kajstura J , Cheng W , Reiss K, Clark WA , et al. Apoptotic and necroticmyocyte cell death are independent contributing variables of infarct size in rate. Lab Invest, 1996; 74: 86.

［6］Dreyer WJ , Michael LH, Nguyen T , et al. Kinetics of C5a release in cardiac dogs experiencing coronary artery ischemia-reperfusion injury. Cardiovasc Res, 1994; 28:437Bardales RH, Hailey S, Xie SS, et al. In situ apoptosis assay for the detection of early acute myocardial infarction. Am J Pathol, 1996;226 (2) : 316.

[7]Ohmo M , Takemura G,Ohno A , et al. So-called apoptotic myocyte in the infarct area may be oncotic myocytes with DNA fragmentation in rabbit heart; analysis by electron microscopic TUNEL(abstr).Circulation, 1997; 96: Ⅰ 2737.

[8] Gottlieb RA ,Burleson KO, Kloner RA , et al. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest, 1994; 94:1621.

[9]Thomopson CB. Apoptosis in the pathogenesis and treatment of diseases. Sicence, 1995; 267: 1456.

[10] Yowe DI, Ames BN. Quantitation of age-related mitochondiral DNA deletions in rat tissues shows that their pattern of accumulation differs from that of humans. Gene, 1998; 209 (122) : 23.

[11]Agocha A ,Lee HW , Eghbali-Webb M. Hypoxia regulates basal and induced DNA synthesis and collagen type 1 production in human cardiac fibroblasts: effects of transforming growth factor-β1, thyroid hormone, angiotensin Ⅱ and basic fibroblast grow th factor. J Mol Cell Cardiol, 1997; 29 (8) : 2233.

[12]Wu2Wong JR, Chiou WJ ,Dickmson R, et al. Endothelin attenuates apoptosis in human smooth muscle cells. Biochem J , 1997; 328(Pt3) : 733 .

[13]Diez J , Panizo A , Herandez M , et al. Cardiomyocyte apoptosis and adiac angiotensin-converting enzyme in spontaneousy hypertension rats. Hypertension, 1997; 30 (5) : 1029.

[14]Olivetti G,A bbi R,Quaini F, et al. Apoptosis in the failing human heart. NEngl J Med , 1997; 336 (16) : 1131.

[15]Aikawa R, Komuro I, Yamazaki T, et al. Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest, 1997; 100(7) : 1813.

[16]Bauriedel G, Schumcking I, Hutter R, et al. Increased apoptosis and necrosis of coronary plaques in unstable angina. Z Kardiol, 1997;86 (11) : 902.

[17]Chernovsky AV,Wang Y,Wong FS,et al.The role of Fas in autoimmune diabetes. Cell, 1997; 89: 17.

[18]Long X, Boluyt MO, Hipolito ML , et al. p53 and the hypoxia-induced apoptosis of cultured neonatal raat cardiac myocytes. J Clin Invest, 1997; 99 (11) : 2635.

[19]Kirshenbaum LA , de-Moissac D. The bal-2 gene product prevents programmed cell death of ventricular myocytes. Circulation, 1997;96 (5) : 1580.

[20]Pierzchalski P, Peiss K, Cheng W , Cirielli C, et al. P53 induces myocyte apoptosis via the activation of the renin-angiotensin system.Exp Cell es, 1997; 234 (1) : 57.

[21]Bialik S, Geenen DL , Sasson IE, et al. Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest, 1997; 100 (6) : 1363.

[22]Tanaka M , Ito T, Adachi S, et al. Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in culutured neonatal rat cardiomyocytes. Circ Res, 1994; 75 (3) : 426.

备注/Memo

备注/Memo:
(收稿1998-11-17　修回1999-07-04)
更新日期/Last Update: 1999-07-01