文章摘要

文章信息/Info

Title:: The expressions of CD11b/CD18 on leucocytes of the CHD patients before and after PTCA and their clinical significance

Keywords:: coronary disease; angioplasty transluminal; percutaneous coronary; CD11b/CD18

摘要:: 探讨不同类型CHD患者白细胞粘附分子的变化和PTCA对白细胞粘附分子表达的影响。选择行冠状动脉造影（CA）和PTCA术的患者27例，将其分为SAP组、UAP组及正常对照组。分别检测CA或PTCA术前、术后6 h,24 h,48 h的白细胞计数及CD11b/CD18在单核细胞和中性粒细胞（PMN）膜上的表达。结果: ①CHD患者血液中单核细胞、PMN的CD11b/CD18表达较健康对照组均显著增加（P＜0.01）,其中UAP组最为明显。②PTCA术后白细胞计数和单核细胞CD11b/CD18表达与术前无明显差异，而PMN膜CD11b/CD18表达在6 h开始升高（P＜0.01）,48 h升高尤为显著。而CA术前后各项检测指标均无差异。结论: CHD患者PMN、单核细胞膜上CD11b/CD18的表达明显增加，粘附性增强，其增加程度与心肌缺血状态有关；PTCA术后PMN膜CD11/CD18表达的上调，可能是冠脉再狭窄的原因之一。

Abstract:: The present atudy was conducted to observe the changes in CD11b/CD18 expressions in different types of CHD patients and the effect of PTCA on CD11b/CD18 expression. Twenty-seven patients who had been given CA and PTCA were chosen and divided into three groups (SAP ,UAP and the control). Leucocyte counts and CD11b/CD18 expression on leucocytes of the three groups were determined befor and 6,24,48 hours after operation. The results were as follows:①The CD11b/CD18 expressions on monocytes and PMNs of the CHD patients were significantly higher than those of the control group (P＜0.01),with the in crease in those of the UAP group most prominent. ②The CD11b/CD18 expressions on the monocytes and leucocyte counts showed no differences in the CHD patients before and after PTCA,but CD11b/CD18 expressions on the PMN gradually increased with the passage of time from 6 h after PTCA,and was the highest 48 h after the operation. It was concluded that both the CD11b/CD18 expressions on PMN and monocyte and the monocytic adherence in the CHD patients obviously increased and that the increased level might be related to the ischemic extent of cardiac muscles. It could be deduced that the increased expression of CD11b/CD18 on PMN after PTCA might play a role in the further narrowing of the coronary artery.