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血管紧张素转化酶基因多态性与内皮功能的研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第2期
页码:
84-86
栏目:
论著
出版日期:
2000-03-25

文章信息/Info

Title:
The deletion/insertion polymorphism of the angiotensin converting enzyme gene and endothelial function
作者:
徐秀英1;  叶珏2;  杜凤和1;  张剑峰1;  惠汝太2
1天坛医院心内科，北京 100050；2阜外医院中德实验室
Author(s):
XU Xiu-ying1; YE Jue2; DU Feng-he1; ZHANG Jian-feng1; HUI Ru-tai2
1Tiantan hospital; Beijing 100050; 2Fuwai hospital; China;
关键词:
血管紧张素转化酶; 基因多态性; 冠状动脉疾病; 内皮功能
Keywords:
angiotensin converting enzyme;  polymorphism of gene; endotheila function; coronary disease
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨血管紧张素转化酶(ACE)基因多态性与冠心病血管内皮功能的关系。方法 采用多聚酶链反应(PCR)技术对24例心肌梗死、56例心绞痛患者、65例正常人的ACE基因型及血浆内皮素(ET)、内皮源性舒张因子(EDRF)进行了检测，以ET/NO作为内皮功能指标。结果 心肌梗死组D等位基因频率显著高于正常对照组，DD型患者中的ET/NO比值较Ⅱ型明显升高(P＜0.05)。结论 DD型心肌梗死患者内皮功能受损较重。
Abstract:
Aim to investigate the association between the deletion/insertion polymorphism of the angiotensin converting enzyme (ACE) gene and endothelial function in coronary heart disease.Methods ACE genotype was determined by PCR,and plasma endothelin (ET-1),endothelium-derived relaxing factor/nitric oxide (EDRF/NO) were meassured in 24 cases of myocardial infarction (MI),56 cases of angina and 65 normal subjects.Results D allele frequency was increased,compared with normal control (52.1% vs 34.6%,P＜0.05), and ET-1/NO ratio was higher in DD homozygotes than in II genotype (0.98±0.32 vs 0.63±0.22,P＜0.05) in patients with MI.Conclusion endothelial dysfunction may related to ACE-DD genotype in patients of MI.

参考文献/References

［1］Staessen JA,Wang JG,Gincchio G,et al. The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk［J］. J Hypertens,1997,15(12Pt2):1579.

［2］Mattu RK,Edward WA,Galton DJ,et al. A DNA variant at the ACE gene locus associated with coronary artery disease in the Gaerphilly Heart Study［J］. Circulation,1995,91(2):270.

［3］郑豪义，戴玉华，邱长春. 血管紧张素转化酶基因的插入/缺失多态性与其血清水平及心肌梗死的关系［J］. 中华心血管杂志，1997，25(1)：34.

［4］Nakai K,Itoh C,Miura Y,et al. Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for coronary artery disease in the Japanese［J］. Circulation,1994,90(5):2199

［5］韩启德，文允镒. 血管生物学［M］. 北京：北京医科大学、中国协和医科大学联合出版社，1997：33～36.

［6］Tiret L,Rigat B,Visvikis S,et al. Evidence from combined segregation and linkage analysis,that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels［J］. Am J Hum Genet,1992,51(1):197.

［7］Costerousse O,Allegrini J,Lopez M,et al. Angiotensin I-converting enzyme in human circulating mononuclear cells:genetic polymorphism of expression in T-lymphocytes［J］. Biochem J,1993,290(Pt1):33.

备注/Memo

备注/Memo:
收稿日期：1999-03-17.
更新日期/Last Update: 2000-03-25