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自主神经张力的变化对三磷酸腺苷终止室上性心动过速的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第3期
页码:
186-188
栏目:
论著
出版日期:
2000-05-25

文章信息/Info

Title:
The effect in autonomic nervous system on supraventricular tachycardia termination by adenosine triphosphate
作者:
赵继良1;  刘恒亮2;  崔进昌1;  郑洪喜1;  周艳秋1;  张敏1;  开芸2;  单新中2
1 沈丘县公疗医院, 河南沈丘466300; 2. 河南省郑州市第五人民医院
Author(s):
ZHAO Ji-ling; LIU Heng-liang; CUI Jin-chang; ZHENG Hong-xi; ZHOU Yian-giu; ZHANG Min; KAI Yun; SHAN Xin-zhong
Free Medical Hospital of Shenqiu,Shenqiu 466300,He′nan,China
关键词:
三磷酸腺苷; 心动过速; 室上性; 阵发性; 异丙基肾上腺素; 阿托品
Keywords:
adenosine triphosphate; tachycardia; supraventricular;  paroxysmal; isoproterenol; atropin
分类号:
R541.71
DOI:
-
文献标识码:
A
摘要:
目的 探讨自主神经张力的变化对三磷酸腺苷(ATP)终止室上性心动过速(SVT)的影响。方法 30例有心动过速病史的患者经食道心房调搏诱发SVT后,随机分为3组,每组10例。Ⅰ组 诱发SVT后,静脉快速推注ATP(剂量由小到大)终止SVT;Ⅱ组 诱发SVT后,先给予异丙基肾上腺素(2 μg/min,5 min)静脉点滴,再用ATP终止;Ⅲ组 诱发SVT后,先静脉推注阿托品(0.04 mg/kg),再给予不同剂量的ATP终止SVT,ATP的剂量依次为 0.15,0.175,0.2,0.225,0.25,0.275,0.3,0.325,0.35和0.375 mg/kg,ATP用药间隔时间为3 min。结果 ATP终止SVT的有效剂量在应用异丙肾上腺素、阿托品后都显著高于基础状态下的剂量(P＜0.05)。结论 自主神经张力的变化对ATP终止室上性心动过速有明显的影响。
Abstract:
This study is to investigate the effect of autonomic nervous system on the termination of supraventricular tachycardia (SVT) by adenosine triphosphate (ATP). Thirty patients with clinically documented SVT were divided into three groups,each consisting of 10 patients. In group Ⅰ,ATP was intravenously injected to terminate SVT during the baseline state after SVT was induced. In group Ⅱ, after SVT was induced,isoproterenol infusion (2 μg/min for 5 min) was administored before ATP was intravenously injected to terminate SVT. In group Ⅲ,after SVT was induced,atropine (0.04 mg/kg) was injected before ATP was intravenously injected to terminate SVT. The doses of ATP were 0.15,0.175,0.2,0.225,0.25,0.275,0.3,0.325,0.35 and 0.375 mg/kg respectively. The minimal doses of ATP needed to terminate SVT after isoproterenol infusion of 2 μg/min (group Ⅱ) or atropin (0.04 mg/kg) imjection (group Ⅲ) were greater than the dose for the baseling state (group Ⅰ). In conclusion,changes in the autonomic nervous system may modulate the ATP dosage required for the termination of SVT.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：1999-06-22.
更新日期/Last Update: 2000-05-25