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内源性类洋地黄物质对高血压病患者左室舒张功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第3期
页码:
189-190
栏目:
论著
出版日期:
2000-05-25

文章信息/Info

Title:
Influence of endogenous digoxin-like substance on left ventricular diastolic function in patients with essential hypertension
作者:
薛玉生;  张宁仔;  王进章;  傅绪杰
第四军医大学唐都医院心内科, 陕西西安710038
Author(s):
XUE Yu-sheng;  ZHANG Ning-zi;  WANG Jin-zhang;  FU Xu-jie
Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, Shaanxi, China
关键词:
内源性类洋地黄物质;  高血压;  心室功能;  左
Keywords:
endogenous digoxin-like substance;  hypertension;  ventricular function;  left
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
测定2 0例正常人和20例高血压病患者的心尖搏动图指数、血清内源性类洋地黄物质 (EDLS)浓度、红细胞膜 Na+ - K+ - ATP酶 (钠泵 )活性及红细胞内钾、钠、钙总量。结果显示 ,与正常人比较 ,高血压病患者的房缩波与E- O垂直高度比值 (A/E- O)明显增高 ,等容舒张期 (IRT)明显延长 ,血清 EDL S浓度明显升高 ,红细胞膜钠泵活性下降 ,红细胞内钠、钙含量升高、钾含量下降 ,且血清 EDL S浓度与 A/E- O,IRT呈显著正相关。提示 EDLS可能参与高血压病患者左室舒张功能异常的形成 ,其机制可能与 EDL S抑制心肌细胞膜钠泵活性并导致细胞内 Ca2 +含量升高有关。
Abstract:
In 20 normal subjects and 20 patients with essential hypertension we tested apexcardiogram indices, serum endogenous digoxin like substance (EDLS) concentration, erythrocyte membrane Na + K + ATPase activity and erythrocyte K, Na and Ca contents. The results showed that in patients with essential hypertension, compared with normal subjects, A/E O ratio was significantly higher, isovolumic relaxation time (IRT) longer, serum EDLS concentration increased, erythrocyte Na and Ca contents elevated but K decreased, and serum EDLS concentration was positively correlated with A/E-O ratio and IRT. It was suggested that EDLS may be in part responsible for left ventricular diastolic dysfunction in patients with essential hypertension, and its mechanism may be that EDLS inhibits myocardial cell membrane Na+-K+-ATPase activity to result in elevated intracellular Ca2+ content.

参考文献/References

［1］ De Warderner HE, MacGregor GA. Dahl’s hypothesis that a saluretic substance may be responsible for a sustained rise in arterial pressure: Its possible role in essential hypertension[J]. Kidney Int, 1980, 18: 1.

[2] 李迪元, 朱鼎良, 袁晓源, 等. 内源性"类洋地黄"物质与原发性高血压关系[J]. 上海医学, 1987, 10 (7) : 399.

[3] Iskandrian AS, Heo J, Segal BL, et al. Left ventricular diastolic function: Evaluation by radionuclide angiography[J].Am Heart J , 1988, 115: 924.

[4] 徐友涵, 宋睦华. 一种简便、灵敏的酶活性测定方法[J]. 生物 化学与生物物理进展, 1986, (4) : 64.

[5] Manolas J , Rutishauser W. Diastolic amplitude time index: A new apexcardiographic index of left ventricular diastolic function in human beings [J]. Am J Cardiol, 1981, 48: 736.

[6] 王进章, 张宁仔, 吴　军. 红细胞内N a+, K+, Ca2+,Mg2+及细胞膜Na+-K+-ATP 酶活性变化对地高辛中毒的诊断价值[J ].中华医学杂志, 1987, 67: 366.

[ 7 ] 马爱群, 刘治全, 杨鼎颐. 人心耳细胞与淋巴细胞、红细胞K+ , Na+ , Ca2+ ,Mg2+ 含量的相关研究[J ]. 中国循环杂志, 1989, 4(2) : 166.

备注/Memo

备注/Memo:
收稿日期：1999-11-15.
更新日期/Last Update: 2000-05-25