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肝素涂层支架植入术对冠心病患者血浆内皮素、丙二醛水平的影响及临床意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第3期
页码:
206-208
栏目:
论著
出版日期:
2000-05-25

文章信息/Info

Title:
Effects of the heparin-coated Wiktor-I stent on the plasma endothelin-1 and malonaldehyde concentrations in patients with coronary artery diseases and clinical significance
作者:
李妍;  李志立;  贾国良;  郭文怡;  李伟杰;  李成祥;  李媛;  李伟;  王小燕　
第四军医大学西京医院心内科, 陕西西安710032
Author(s):
LI Yan;  LI Zhi-li;  JIA Guo-liang; GUO Wen-yi; LI Wei-jie; LI Cheng-xiang; LI Yuan; LI wei; WANG Xiao-yan
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032,Shaanxi,China
关键词:
肝素涂层支架; 内皮素; 丙二醛; 冠状动脉疾病
Keywords:
heparin-coated stent;  endothelin-1;  malonaldehy;  coronary disease
分类号:
Q952.1
DOI:
-
文献标识码:
A
摘要:
目的 研究肝素涂层支架植入术对冠状及体循环中血浆内皮素(ET）和丙二醛(MDA)水平的影响。方法　选择冠心病患者30 例，随机植入普通无涂层支架(NCS）16例和肝素涂层支架(HCS）14例，于手术前后不同时间点，同时采集冠状静脉窦和外周肘静脉血检测血浆ET-1和MDA浓度。结果　①NCS组 ET-1水平在支架后即刻和支架后12 h呈现大小两个高峰，MDA水平在支架后5 min达高峰(P＜0.01)；②HCS组 ET-1水平在支架后5 min，10 min和12 h明显低于同时间点NCS组水平(P值分别＜0.05,＜0.01和＜0.05)，MDA水平于支架后5min至术后1 d均明显低于NCS组(均P＜0.05)。 结论　HCS可降低术后ET-1和MDA水平，这可能对支架植入术后防止急性血管痉挛和(亚)急性血栓形成的发生有一定保护作用。
Abstract:
The purpose of our study was to investigate the effects of heparin-coated Wiktor-I stent on the concentrations of plasma endothelin-1(ET-1) and malondialdehyde (MDA). Non-coated stent(NCS)(n=16) and heparin-coated stent(HCS) (n=14) were randomly implanted into 30 patients with coronary artery diseases. Circulating ET-1 and MDA levels were measured in both groups of patients at the paired sampling sites: the coronary sinus and peripheral vein. Results were as follows: 1. NCS group: plasma ET-1 concentration exhibited two peaks immediately and 12 h after the implant, MDA level reached the peak 5 min after the implant (P＜0.01); 2. HCS group: ET-1 level was decreased dramatically compared with that in NCS group 5 min, 10 min and 12 hours after the implant (P＜0.05,P＜0.01 and P＜0.05, respectively), and the same with MDA level from 5min to 1d after the implant(all P＜0.05). It can be concluded that HCS can decrease post-stent ET-1 and MDA level, so it can be inferred that HCS is helpful in preventing post-stent acute vasospasm and (sub)acute thrombosis.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：1999-06-22.
更新日期/Last Update: 2000-05-25