我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

肝硬化门脉高压鼠脾脏舒缩功能改变与α肾上腺素受体变化的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第4期
页码:
260-262
栏目:
论著
出版日期:
2000-08-01

文章信息/Info

Title:
The relationship between contractile changes and alpha adrenoceptor regulation on spleen of rats with liver cirrhosis and portal hypertension
作者:
保庭毅1;  臧益民2
第四军医大学: 1. 唐都医院泌尿外科, 陕西西安710038; 2. 生理学教研室
Author(s):
BAO Ting-yi1;  ZANG Yi-min2
1.Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an Shaanxi 710038, China; 2.Department of Physiology
关键词:
高血压; 门脉; 肝硬化; 脾; 受体; 肾上腺素能α
Keywords:
hypertension; portal; spleen; liver cirrhosis; receptors; adrenergic; alpha
分类号:
R657.34
DOI:
-
文献标识码:
A
摘要:
目的 探讨脾脏舒缩功能改变与α受体调控改变的关系。方法 采用药理学受体分析技术，测定两组大鼠脾脏α受体在应用拮抗剂前后，PA2，PD2，KA，EC50，Rmax,q值受体占有率等。结果 肝硬化门脉高压鼠的脾脏α受体对去甲肾上腺素的亲和力、敏感性、受体占有率及脾脏收缩效应均显著低于正常鼠，但α储备受体都高于正常鼠。结论 门脉高压鼠脾脏α受体处于“低敏状态”，脾脏舒张功能强于收缩的失衡状态，导致脾脏充血肿大。因此，肝硬化门脉高压情况下脾脏“低敏状态”的α受体可能是导致脾脏充血性肿大的原因之一。
Abstract:
AIM To investigate the relationship between the alpha-adrenoceptor regulation and contractile changes of spleen by using pharmacological methods. METHODS According to the NE-induced contractile curve of preparations before and after antagonist treatment,the data of EC50,Potency, maximal contraction and agonist dissociation constant (KA) q values fractional receptor occupancy were calculated. RESULTS ①The NE-induced contractile curve of PHT group shifted to the right,the maximal contractions of PHT group were lower than those of control group. ②The KA and KA/EC50 values of PHT group were more than those of control group. but the q values and fractional receptor occupancy of PHT group were less than those of control group. CONCLUSION Because the affinity,sensitivity and maximal contraction to norepinephrine in spleen of PHT group were significantlylower than that of control,the function of spleen contraction was decreased. The alpha-adrenoceptor of spleen in PHT group was “lower sensitivity”. It related to the formation of congestive splenomegaly.

参考文献/References

[1] 保庭毅，何泽生，吴金生，等. 大鼠脾脏收缩功能与α肾上腺素受体亚型的调节［J］. 心功能杂志，1999，11(2)：95.

［2］ Cabanac A, Folkow LP, Blix AS. Volume capacity and contraction control of the seal spleen［J］. J Appl Physiol, 1997,82(6): 1989.

［3］ 徐端正. 用改良等效法估计药物-受体解离常数. 中国药理学会数学药理专业委员会编. 药理学进展(1982)数学药理分册［M］. 北京：人民卫生出版社，1983:71～80.

［4］ Oriowo MA. Functional characterization of alpha1-adrenoceptor subtypes in the rabbit spleen［J］. Naunyn Schmiedebergs Arch Pharmacol, 1998,358(3): 301.

［5］ Wikberg Matsson A, Wikberg JE, Uhlen S. Characterization of alpha1-adrenoceptor subtypes in the pig［J］. Eur J Pharmacol, 1998,347(2-3): 301.

［6］ Yang M, Reese J, Cotecchia S, et al. Murine alpha 1-adrenoceptor subtypes. I. Radioligand binding studies［J］. J Pharmacol Exp Ther, 1998， 286(2): 841.

［7］ Eltze M. In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors［J］. Eur J Pharmacol, 1996, 295(1): 69.

［8］ Buscher R, Heeks C, Taguchi K, et al. Comparison of guinea-pig, bovine and rat alpha 1-adrenoceptor subtypes［J］. Br J Pharmacol, 1996,117(4): 703.

［9］ Burt RP, Chapple CR, Marshall I. The role of capacitative Ca2+ influx in the alpha 1B-adrenoceptor-mediated contraction to phenylephrine of the rat spleen［J］. Br J Pharmacol, 1995,116(4): 2327.

备注/Memo

备注/Memo:
收稿日期：2000-03-12.
更新日期/Last Update: 2000-08-01