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冠状动脉内直接注射硝基甘油抑制PTCA术后血小板的活化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第5期
页码:
358-360
栏目:
论著
出版日期:
2000-10-25

文章信息/Info

Title:
Inhibition of direct intra-coronary injection of nitroglycerin on platelet acti vation after percutaneous transluminal coronary angioplasty
作者:
马颖艳;  贾国良;  程何祥;  郭文怡;  李媛;  李伟;  王小燕
第四军医大学西京医院心内科, 陕西西安710032
Author(s):
MA Ying-yan; 　JIA Guo-liang; 　CHENG He-xiang; 　GUO Wen-yi; 　LI Yuan; 　LI Wei; 　WANG Xiao-yan
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, X i'an Shaanxi 710032， China
关键词:
血管成形术; 经腔; 经皮冠状动脉; 血小板; 血小板衍化生长因子; 硝; 基甘油; α-颗粒膜蛋白; 血栓素B2;  6-酮-前列腺素F1a
Keywords:
angioplasty; transluminal; percutaneous　coronary ;  nitro gl ycerin platelet α granule membrane protein-140;  thromboxane B2; 6-keto -prostaglandin F1α; platelet derived growth factor
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 研究冠状动脉内直接注射硝基甘油抑制PTCA术后血小板的活 化。方法 应用放 免法测定38例稳定心绞痛患者PTCA前后血小板膜表面α-颗粒膜蛋白(GMP-140)分子数和 血 浆血栓素B2(TxB2)、血浆6-酮-前列腺素F1α(6-Keto-PGF1α)浓度, 以及血小板衍化生长因子(PDGF)和血小板聚集 率。结果 冠脉内直接注射硝基甘油的患者PTCA前后上述指标无明显变化，而 未用药的患 者PTCA术后5 min血小板膜表面GMP-140及血浆TxB2，PDGF和血小板聚集率均明显增高,术 后1 0 min达到高峰,30 min降至正常。结论 冠脉内直接注射硝基甘油可以抑制PTC A术后血小板的活化。
Abstract:
AIM To study effect of direct intra-coronary injection of nitr o glycerin on platelet activation after percutaneous transluminal coronary angiopl asty(PTCA). METHODS Number of platelet α granule membrane protein- 140 (GMP-140) and plasma concentration of thromboxane B2 (TxB2) and 6-keto -prostaglandinF1α(6-keto-PGF1α) were determined by radioimmunoa ssay before and after PTCA in 38 patients with stable angina pectoris. Platelet derived growth factor(PDGF) and platelet aggregatio n rate were also determined. RESULTS In patients without receiving nitroglycerin, platelet GMP-140,plasma concentration of TxB2, PDGF and plate let aggregation rate increased significantly 5 min after PTCA;which reached peak value t en min after PTCA and decreased to normal level 30 min after PTCA. But in patients having received direct intra-coronary injection of nitroglycerin, the s e values did not change before and after PTCA. CONCLUSION Platelet ac tivation oc cures after PTCA,which can be inhibited by direct intra-coranary injection of nitroglycerin.

参考文献/References

［1］ 马颖艳 贾国良 郑昌柱,等,经皮冠状动脉腔内成形术前后血小板功能及前列 腺素水平的变化及其临床意义［J］. 中华心血管病杂志, 1999,27(1):33.

［2］ Nomenclature and criteria for diagnosis of ischemic heart disease. Report of the joint international society and Federation of Cardiology/World heart organi zation task force on standardization of clinical nomenclature［J］. Circulatio n, 1979,59(3):607.

［3］ 吴国新,李健勇,李佩霞,等. 血小板表面及血浆内α-颗粒膜蛋白的放射免疫测定［J ］. 中华血液学杂志 1992,13( 1):99.

［4］ 李振甲. 实用放射免疫学［M］.北京:科学技术文献出版社，1989.198～221.

［5］ Heldin CH. Platelet-derived growth factor isolation by a large-scale p rocedure and analysis of subunit composition［J］. Biochme J, 1981, 193(3):9 07.

［6］ Langford EJ, Brown AS, Wainurig RJ, et al. Inhibition of platelet acti vity by s-nitrosoglutathione daring coronary angioplasty［J］. Lancet， 1994,344(8935):1458.

［7］ Stenbery PE, Mcever RP, Shuman MA, et al. A platelet alpha-gr anule membrane pr otein(GMP-140) is expressed on the plasma after activation［J］. J Cell Biolo gy. 1985,101(3):880.

［8］Hanke H, Strohschneider T, Oberhoff M, et al. Time course of smoot h muscle c ell proliferation in the intima and media of arteries following experimental ang ioplasty［J］. Circ Res， 1990,67(3):651.

备注/Memo

备注/Memo:
收稿日期：1999-10-25.
更新日期/Last Update: 2000-10-25