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|本期目录/Table of Contents|

克罗卡林和JTV-506对大鼠离体心脏心功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第6期
页码:
463-465
栏目:
论著
出版日期:
2000-12-01

文章信息/Info

Title:
Effects of CROMAKALIM and JTV-506 on the cardiac function of isolated rat's heart
作者:
贾大林;  郑晓伟;  齐国先;  胡　健;  曾定尹
中国医科大学第一临床学院循环内科, 辽宁沈阳110001
Author(s):
JIA Da-lin;  ZHENG Xiao-wei;  QI Guo-xian;  HU Jianm;  ZENG Ding-yin
Department of Cardiology, First Clinical College, China Medical University, Shenyang Liaoning 110001, China
关键词:
克罗卡林;  JTV-506;  心室功能;  大鼠
Keywords:
CROMAKALIM;  JTV-506;  heart function;  rats
分类号:
R331.31,R972.4
DOI:
-
文献标识码:
A
摘要:
目的 对比两种不同的 ATP敏感性钾通道 (KATP通道 )开放剂克罗卡林 (CR)和 JTV- 5 0 6 (JTV)对大鼠离体心脏心功能的影响及缺血后的心脏保护作用。方法 用含不同药物浓度的灌注液灌注心脏并将心脏进行完全缺血 2 5min,再灌注 30 m in,观察各组心功能的变化。结果 1～ 2 0μm ol/ L CR及 JTV均能显著增加冠脉灌注量 ,1μm ol/ L的 CR和 JTV较对照组均有改善缺血后心功能的作用 ,其作用可完全被格列本脲所阻断。结论 两药均有明显冠脉扩张作用 ,大剂量应用可降低心脏收缩功能 ,用不影响心功能的剂量两者均有对缺血后心脏的保护作用 ,此作用与ATP敏感性钾通道开放有关。
Abstract:
AIM To compare the effects of two different ATP sensitive K + channel openers-CROMAKALIM (CR) and JTV 506 (JTV) on the function of isolated rat's heart and their cardiac protection effects on post ischemic heart. METHODS Isolated rat's heart was perfused by CR or JTV in different concentration and was subjected to 25 min complete ischemia followed by 30 min reperfusion. The change in cardiac function was observed. RESULTS Both 1~20 μmol/L CR and JTV could increase the flow of coronary artery obviously 1 μmol/L they could also improve the cardiac function after ischemia. This effect could be completely blocked by glibenclamide. CONSLUSION CR and JTV both had the effect to dilate the coronary artery. They decreased cardiac contractile function when administrated in large dosage. They could protect the post-ischemic heart when administrated in dosage that didn't affect cardiac contractile function. This effect was related to the opening of ATP sensitive K+ channel.

参考文献/References

[1] Grover GJ , Mc Cullough JR, Henry DE, et al. Anti-ischemic effects of the potassium channel activators pinacidil and CROMAKALIM and the reversal of the effects with the potassium channel blocker glyburide [J]. J Pharmacol Exp Ther, 1989, 251: 98.

[2] Hirata Y,Aisaka K. Effect of JTV-2506, a novel vasodilator, on coronary blood flow in concious dogs[J]. Am J Physiol, 1991, 261: H2082.

[3] Samaha FF, Heineman FW , Ince C, et al. ATP-sensitive potassium channel is essential to maintain coronary vascular tone in vivo[J]. Am J Phy siol, 1992, 262: C1220.

[4] Ohta H, Jinno Y, Harad K, et al. Cardioprotective effects of KRN2391 and nicorandil on ischemic dysfunction in perfused rat heart [J]. Eur J Pharmacol, 1991, 204: 171.

[5] Nakaya H, Takeda Y, Tohse N , et al. Effects of ATP-sensitive K+ channel blockers on the action potential shortening in hypoxic and ischemic myocardium [J]. Br J Pharmacol, 1991,103: 1019.

[6] Lopez JR, Ghanbari RA , Terzic A. A KATP channel opener protects cardiomyocytes from Ca2+ waves: a laser confocal microscopy study[J]. Am J Physiol, 1996, 270: H1384.

[7] Shigematsu S, Sato T, Abe T, et al. Pharmacological evidence for the persistent activation of ATP-sensitive K+ channels in early phase of reperfusion and its protective role against myocardial stunning[J]. Circulation, 1995, 92: 2266.

[8]McPherson CD, Pierce GN , Cole WC. Ischemic cardioprotection by ATP-sensitive K+ channels involves high-energy phosphate preservation[J]. Am J Physiol, 1993, 265: H1809.

备注/Memo

备注/Memo:
收稿日期：1999-11-08.
更新日期/Last Update: 2000-12-01