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|本期目录/Table of Contents|

冠状动脉造影和PTCA术对冠心病纤溶活性的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第2期
页码:
141-143
栏目:
论著
出版日期:
2001-03-01

文章信息/Info

Title:
Effect of fibrinolytic activity in patients with coronary artery disease undergoing select coronary arteriography and PTCA
作者:
邱建 1; 罗炎华2
1．广州军区广州总医院心血管内科，广东广州510010;2．广州军区疗养院
Author(s):
QIU Jian1 ; LUO Yah-hua2
1．Department of Cardiology，General Hospital of Guangzhou Army，Guangzhou Guangdong 510010，China
关键词:
冠状血管适影术; 选择性; 血管成形术; 经腔; 经皮冠状动脉; 冠状动脉疾病; 组织型纤溶酶原激活物; 纤溶酶原激活物抑制物
Keywords:
coronary angiography; select; angioplasty; transluminal; percutanous coronary; coronary disease; tissue-type plasminogen activator antigen; plasminogen activator inhibitor type 1
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察选择性冠状动脉造影(SCA)和PTCA对冠心病纤溶活性的影响。方法 对接受SCA的45例患者和PTCA术后19例患者的血浆组织型纤溶酶原激活物抗原(t-PA：Ag)、纤溶酶原激活物抑制物(PAI1)和纤维蛋白二聚体(DD)含量进行动态观测。结果 ①SCA后SCA正常组、稳定型和不稳定型心绞痛组t-PA：Ag含量均显著升高(P
Abstract:
AIM To investigate the effects of fibrinolytic activity in patients with coronary artery disease underwent select coronary arterlography (SCA)and percutanous translumina1 coronary angioplasty(PTCA)．METHODS Forty-five patients underwent SCA and nineteen underwent PTCA．RESULTS The plasma levels of tissue-type plasminogen activator antigen (t-PA ：Ag) and corss linked fibrin degradation products(D dimer，DD)raised significantly in the groups with stable or unstable angina and the normal group after underwent SCA．At 24 h，elevated levels of PA：Ag decreased but DD at 72 h．The elevated 1evels of t-PA{Ag in normal group was higher than stable or unstable angina groups significantly．The activity of plasminogen activator inhibitor type 1(PAI1)was unchanged．Underwent PTCA caused a significant increase in the plasma 1evels of t，PA：Ag and DD and the activity of PAI1．The elevated Ievels of activity of PAII decreased to the pretreatment level during the period of 3 d after PTCA，but t-PA：Ag during 7 d-In 7 d the 1evels of DD were higher than before underwent PTCA．CONCLUSION The function of deposition and release PA ：Ag weaken in patients with coronary artery disease．The fibrinolytic activitv raise after underwent SCA and PTCA，because of taken the drugs of anti-platelet and heparin on pretreatment and after treated.

参考文献/References

[1]Cheandler WL,Velth RC,Fellingshern GW，et al.Fibrinolytic response during exercise and epinephcine infusion in the same subjects[J]．J Am Coll Cardiol，1992,19:1412.

[2]Jansson JH，Nilsson TK,Olofsson BO,et al.Tissue plasminogea activator and other risk factors as predictors of cardiovascular in patients with angina．pectoris[J]．Eur Heart J．1991,12：156．

[3]Wielzorek I,Iudlan CA,Fox KA,et al.Tissue type plasminogen activator and plasminogen activator inhibitor activities as predictors of advers events in unstable angina[J].Am J Cardiol．l994，74:424．

[4]邓鹤秋，郭衡山，钱学贤，等．纤溶系统缺陷在运动所致心肌缺血中的临床意义[J]．中华内科杂志。1995,34:305．

[5]Prisco D,Panniccia R,Gensini GF，et a1．Effect of low dose haparin treatment of fibrinolysis in patient with previous myocaridal infarction[J]．Haemastasis,1993,23:308．

[6]Aznar J，Estelles A,Tormo G,et al.Plesminogen activator inhibitor aetivity and other fibrinolytic variables in patients with coronary artery disease[J].Br Heart J.1988，59：535.

备注/Memo

备注/Memo:
收稿日期：2000-03-28.
更新日期/Last Update: 2001-03-01