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高血压病患者血浆降钙素基因相关肽和内皮素浓度的变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第3期
页码:
188-189, 192
栏目:
论著
出版日期:
2001-05-01

文章信息/Info

Title:
Changes in plasma calcitonin gene-related peptide and endothelin concentration in patients with essential hypertension
作者:
叶季鲜1;  李红梅1;  黄　静2;  杨春姣1;  李　敏3
解放军第323 医院: 11 心内科, 21 中西科, 31 检验科, 陕西西安710054
Author(s):
YE Ji-xian1;  LI Hong-mei1;  HUANG Jing2;  YANG Chun-jiao1;  LI Min3
1. Department of Cardiology. No.323 Hospital of PLA. Xi'an Shaanxi 710054. China
关键词:
高血压;  降钙素;  基因相关肽;  内皮素
Keywords:
hypertension;  calcitonin;  gene related peptide;  endothelin
分类号:
R541.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨血浆降钙素基因相关肽 (CGRP)和内皮素 (ET)与高血压病之间关系。方法 放射免疫方法检测 25例正常人和36例高血压病患者降压治疗前后血浆CGRP和ET浓度 ,同时测量高血压病患者血压。结果 1高血压病患者血浆CGRP浓度低于正常人,与平均动脉压呈负相关;ET浓度高于正常人,与平均动脉压呈正相关。2有效降压治疗后 ,高血压病患者血浆 CGRP浓度回升 ,ET浓度下降 ,CGRP/ ET比值明显升高。结论 血浆CGRP和ET浓度失衡可能是高血压病发生的重要原因之一;有效降血压可能与CGRP和ET的变化有关。
Abstract:
AIM To investingate the relationship between the plasma calcitonin gene related peptide (CGRP),endothelin (ET) in patient with essential hypertension. METHODS We determined the plasma concentration of CGRP and ET in 25 normotension people and 36 patients with essential hypertension before and after anti hypertension treatment with radioimmunoassay,and measured the blood pressure of essential hypertension patients. RESULTS ①The plasma CGRP concentration in patients with essential hypertension was lower than that in the normotension people, and there was a negative relation ship between it and the mean artery pressure. The plasma ET concentration in patients with essential hypertension was higher than that in the normotension people, and there was a positive relationship between it and the mean artery pressure. ② Af ter effective antihypertension treatment, the plasma CGRP concentration in the hypertensive was elevated, the plasma ET concentration was lowered, and the rate of CGRP/ET was elevated. CONCLUSION The unbalance between plasma CGRP and ET concentration might be an important reason for essential hypertension, and the effective antihypertension treatment migh t regulate the balance between this pair of vasoactive substances.

参考文献/References

[1] Franco CA , Gennari C, Nami R, et al. Cardiovascular effects of calcitonin gene-related peptide I and II in man [J]. Circ Res, 1987, 60: 393.

[2] Tanirisa Y, Frishman WH, Kumar A. Endothelin and endothelin antagonism: Role in cardiovascular health and disease [J]. Am Heart J, 1995, 130 (3, Part 1) : 501.

[3] Lappe RW. Hemodynamic effects of calcitonin gene-related peptide in consicous rats[J]. Regulpept, 1987, 19: 307.

[4] Yoshiyu T, Isamu M, Wu PS, et al. Effects of an endothelin receptor antagonistin rats with cyclosporine-induced hypertension[J]. Hypertension, 1995, 26: 932.

[5] Ryoyu T, Isamu M. endocrine and auto-paracrine factors in the pathogenesis of primary hypercension[J]. Hypertens Res, 1995, 18: 171.

[6] 李红梅, 裴建明, 朱妙章, 等. 降钙素基因相关肽的抗室颤作用[J]. 心功能杂志, 1997, 9 (1) : 5.

[7] Gangule PR, Supowit SC, Winmalawansu SJ , et al. calcitonin gene-related peptide is a depressor in NG-nitro-L-arginine methyl ester-induced hypertension during pregnancy [J]. Hypertension, 1997, 29 (1 pt 2) : 248.

[8] 吴宏超, 钱学贤, 李立平. 降钙素基因相关肽对顿抑心肌心功能的影响[J]. 心功能杂志, 1999, 11 (4) : 220.

备注/Memo

备注/Memo:
收稿日期：2000-02-14.
更新日期/Last Update: 2001-05-01