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|本期目录/Table of Contents|

磁化支架安置术后血浆纤溶活性变化及临床意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第3期
页码:
211-213
栏目:
论著
出版日期:
2001-05-01

文章信息/Info

Title:
Influences of intracoronary magnetic stents on coronary sinus fibrinolysis activities in patients with coronary artery diseases
作者:
周 宁;  贾国良;  李成祥;  李伟杰;  吕安林;  王海昌;  张清;  王小燕
第四军医大学西京医院心脏内科,陕西西安710032
Author(s):
ZHOU Ning;  JIA Guo-liang;  LI Cheng-xiang;  LI Wei-jie;  LU An-lin;  WANG Hai-chang;  ZHANG Qing;  WANG Xiao-yan
Department of cardiology,Xijing Hospital, Fourth Military Medical University PLA, Xi'an Shaanxi 710032, China
关键词:
磁场;  冠状动脉疾病;  冠状动脉内支架安置术;  纤维蛋白溶解活性;  组织型纤溶酶原激活物;  纤溶酶原激活物抑制剂
Keywords:
magnetic field;  coronary disease;  intracoronary stenting;  fibrinolysis activity; tissue-type plasminogen activator; plasminogen activator inhibitor-1
分类号:
R454.1; R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察冠心病患者冠状动脉内支架安置术(ICS)后冠状窦血浆组织型纤溶酶原激活物(t-PA)和纤溶酶原激活物抑制剂-1(PAI-1)活性的动态变化,探讨磁化支架对术后再狭窄防治的作用机制。方法 冠心病患者38例,随机安置普通支架18例(I组),磁化支架20例(II组),分别于PTCA前、ICS后即刻、6 h时自冠状窦采血来检测血浆t-PA和PAI-1的活性。结果 两组患者的t-PA活性在术后即刻均降低,而术后6 h II组的t-PA活性较之I组有明显恢复(P<0.05)。相反,术后即刻两组患者的PAI-1活性均明显升高(P<0.01);然而,在术后6 h, II组 的PAI-1活性已恢复到术前水平(P<0.05)。结论 磁化支架可有效促进冠脉循环纤溶活性的恢复,可能对再狭窄有防治作用。
Abstract:
AIM To investigate the effects of intracoronary magnetic stents on plasma tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1(PAI-1)activities.METHODS Non-magnetic stents(NMS,n=18) and magnetic stents (MS,n=20) were randomly implanted in 38 consecutive patients with coronary artery diseases .Blood was drawed from coronary sinus to measure fibrinolysis activity.RESULTS The t-PA activities in the two groups were lowered immediately after stenting. However, the t-PA activity in MS group almost was increased to the baseline level at 6 h, compaired with that of NMS group (P<0.05).On the contrary, the PAI-1 activities in both of the groups were markedly elevated immediately after stenting(P<0.01). Nevertheless,the one in MS group was restored to the pre-PTCA level at 6 h .CONCLUSION Intracoronary magnetic stents may be beneficial to restoration of fibrinolysis activity in coronary sinus plasm after angioplasty, which can be helpful in preventing restenosis.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2001-01-11.
更新日期/Last Update: 2001-05-01