我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

血管紧张素Ⅱ受体第二亚型(AT_2-R)的研究进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第3期
页码:
231-233
栏目:
综述
出版日期:
2001-05-01

文章信息/Info

Title:
-
作者:
李国权 综述;  乔宏庆 审校
第四军医大学西京医院核医学科, 陕西西安 710032
Author(s):
-
关键词:
受体; 血管紧张素Ⅱ; 第二亚型; 基因表达调控; 信号转导
Keywords:
-
分类号:
Q71
DOI:
-
文献标识码:
A
摘要:
对血管紧张素Ⅱ(ATⅡ)在机体内特异性受体第二亚型结构、信号转导和病理生理功能的研究已成为近年来的一个研究热点。作者综述了其分子结构、基因表达与调控及其病理生理作用的研究进展。
Abstract:
-

参考文献/References

[1] Mukoyama M, Nakajima M, Horiuchi M,et al. Expression cloning of type 2 angiotensinⅡreceptor reveals a unique class of seven-transmembrane receptors[J].J Biol Chem, 1993, 268: 24539.

[2] Ichiki T , Labosky PA, Shiota c,et al. Effects on blood pressure and exploratory of mice laking angiotensinⅡtype 2 receptor[J].Nature, 1995, 377:748.

[3] Heerding JN, Yee DK, Jacobs SL,et al. Mutational analysis of the angiotensinⅡtype 2 receptor :contribution of conserved extracellular amino acids[J].Regul Pept, 1997, 72:97.

[4] Nakajima M, Mukoyama M, Pratt M,et al. Cloning of cDNA and analysis of the gene for mouse angiotensinⅡtype 2 receptor [J] .Biochem Biophys Res Commun,1993,197:393.

[5] Martin MM, Su B, Elton TS,et al. Molecular cloning of the human angiotensinⅡtype 2 receptor DNA[J].Biochem Biophys Res Commun,1994, 205:645.

[6] Kizima K, Matsubara H, Murasawa S,et al. Regulation of angiotensinⅡtype 2 receptor gene by the protein kinase C-calcium pathway[J].Hypertension, 1996,27:529.

[7] Kizima K, Matsubara H, Murasawa S,et al. Gene transcription of angiotensinⅡtype 2 receptor is repressed by growth factors and glucocorticoids in PC12 cells [J].Biochem Biophys Res Commun, 1995,216:359.

[8] Ichiki T, Kambayashi Y, Inagami T. Multiple growth factors modulate mRNA expression of angiotensinⅡtype-2 receptor in R3T3 cells[J].Cir Res, 1995, 77:1070

[9] Ichiki T, Inagami T. Transcriptional regulation of the mouse angiotensinⅡtype 2 receptor gene[J].Hypertension, 1995, 25: 720.

[10] Tsuzuki S, Eguchi S, Inagami T,et al. Inhibition of cell proliferation and activation of protein tyrosine phosphatae mediated by angiotensinⅡtype 2 (AT2) receptor in R3T3 cells[J].Biochem Biophys Res Commun, 1996, 228:825.

[11] Horiuchi M, Hayashida W, kambe T,et al. Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-acti-vated protein kinase phosphatae-1 and induce apoptosis[J].J Biol Chem, 1997, 272:19022.

[12] Zhang J, Pratt RE. The AT2receptor selectively associates with Giα2and Giα3in the rat fetus[J].J Biol Chem, 1996, 271: 15026.

[13] Gohlke P, Pees C, Unger T. AT2receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism[J].Hypertension, 1998, 31: 349.

[14] Tsutsumi Y, Matsubara H, Ohkubo N,et al. AngiotensinⅡtype 2 receptor is up regulated in human heart with interstitial fibrosis , and cardiac fibroblasts are the major cell type for its expression[J].Circ Res, 1998, 83:1035.

备注/Memo

备注/Memo:
收稿日期：2000-02-17.
更新日期/Last Update: 2001-05-01