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|本期目录/Table of Contents|

毛花甙丙诱发犬心房颤动的实验研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第4期
页码:
277-278
栏目:
论著
出版日期:
2001-07-01

文章信息/Info

Title:
Facilitating of induced atrial fibrillation by deslanosidum in dogs
作者:
侯允天1;  杜日映1;  王　斌1;  彭整军2;  张孝忠2;  赵玉娟2
1.第四军医大学唐都医院心内科, 陕西西安, 710038; 2.哈尔滨解放军211 医院心内科
Author(s):
HOU Yun-tian1;  DU Ri-ying1;  WANG Bin1;  PENG Zheng-jun2;  ZHANG Xiao-zhong2;  ZHAO Yu-juan2
1.Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi’an Shaanxi 710038, China; 2.Department of Cardiology, 211 Hospital of PLA
关键词:
毛花甙丙;  心房颤动
Keywords:
deslanosidum;  atrial fibrillation
分类号:
R542.7
DOI:
-
文献标识码:
A
摘要:
目的 观察毛花甙丙对犬心房颤动诱发的影响。方法 采用心外膜标测技术, 对8只犬在应用毛花甙丙前后的左、右心耳有效不应期, 不应期离散, 心房颤动诱发阈值及心房颤动持续时间进行比较。结果 毛花甙丙使心房颤动的诱发阈值明显降低, 易化心房颤动的诱发。结论 毛花甙丙易化心房颤动的诱发提示临床治疗急性心房颤动时应慎用洋地黄类药物。
Abstract:
AIM To investigate the effects of deslanosidum on induced atrial fibrillation (AF) in dogs. METHODS With epicardial mapping technique, the effective refractory period, the dispersion of refractriness, the thresholds and durations of induced AF at dog’s auricles before and after the administration of deslanosidum were compared respectively. RESULTS Deslanosidum delayed the thresholds of induced AF significantly and faciliated the induction of AF. CONCLUSION The facilitating of induced AF by deslanosidum suggested a prudent use of digitalis in treatment of acute AF.

参考文献/References

[1] Tieleman RG, Blaauw Y, Van Gelder IC, et al. Digoxin delays recovery from tachycardia-induced electrical remodeling of the atria[J]. Circulation, 1999, 100(5): 1836-1842.

[2] Zaqqa M , Afshar H, Rasekh A , et al. Predictors of conversion to sinus rhythm using Ibutilide for atrial fibrillation or flutter [J]. Am J Cardiol, 2000, 85(1): 112-114.

[3] Deliargyris EN , Raymond RJ , Guzzo JA , et al. Preoperative factors predisposing to early post operative atrial fibrillation after isolated coronary artery bypass grafting [J]. Am J Cardiol, 2000, 85 (3) : 763-764.

[4] Smith TW. Digitalis: Mechanisms of action and clinical use[J].N Engl J Med , 1988, 318(6): 358-365.

[5] Goette A , Honeycutt C, Langberg JJ. Electrical remodeling in atrial fibrillation: Time course and mechanisms[J]. Circulation,1996, 94(6): 2968-2974.

备注/Memo

备注/Memo:
收稿日期：2000-07-04.
更新日期/Last Update: 2001-07-01