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冠心病患者性激素水平失衡的研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第5期
页码:
343-345
栏目:
论著
出版日期:
2001-09-01

文章信息/Info

Title:
A study of endogenous sex hormone disorder in patients with coronary heart disease
作者:
袁　铭;  贾国良;  王海昌
第四军医大学西京医院心内科, 陕西西安710032
Author(s):
YUAN Ming ;  JIA Guo-liang ; WANG Hai-chang
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an Shaanxi 710032, China
关键词:
冠状动脉疾病;  性激素;  血脂
Keywords:
coronary disease;  sex hormone;  plasma lipid
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 研究冠心病患者性激素水平的变化。方法 选择冠心病患者50 例, 用放射免疫法测定血清雌二醇(E2)、孕酮(P)、促卵泡刺激素(FSH)、促黄体生成素(LH)、睾酮(T )、泌乳素(PRL ) 及生长激素(GH) 的变化; 采用酶法观测空腹总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL ) 及低密度脂蛋白胆固醇(LDL 2C) 的变化。结果 ①男性冠心病组与对照组比E2、P 均升高(P < 0. 05) , T 水平亦明显下降(P < 0. 01) ; 女性冠心病组与对照比, P 水平均显著升高(P < 0. 01) , E2 水平下降(P < 0. 05)。②男性冠心病患者TC, TG,LDL 2C 均显著高于对照组(P < 0. 01) ,HDL 显著低于对照组(P < 0. 01) ; 女性冠心病患者TC, TG,LDL 2C 均高于对照组(P < 0. 05) ,HDL 低于对照(P <0. 05)。结论 冠心病患者存在血脂代谢异常。但男性与女性冠心病患者的性激素水平失衡存在差异: 男性E2, P 升高, T 降低, 女性P 升高, E2 降低。
Abstract:
AIM To study the changes of sex hormones in patients with coronary heart disease(CHD). METHODS Fifty CHD patients defected by coronary artery angiography were studied by comparition. Serum estradiol (E2) , testo serone (T) , prolaction (P) , follicle stimulating hormone(FSH) , luternizing hormone (LH ) and growth hormone ( GH ) were measured with radio immunoassy. Plasma total cholesterol (TC) , triglycerides (TG) , low density lipoprotein cholesterol (LDL -C) and high density lipoprotein (HDL )were estimated by enzymatic method.RESULTS As far as sex hormone were concerned, in male patients, E2 and P levels were higher(P < 0. 05) but T levels were lower (P < 0. 01) than those of the controls but in female patients P levels were higher (P < 0. 01) , and E2 levels were lower (P < 0. 05) than those of the control. TC,TG and LDL -C were significantly increased in male patients (P < 0. 01) but HDL were decreased( P < 0101). For female patients, TC, TG and LDL -C were increased (P < 0. 05) and HDL were decreased (P < 0. 05). Compared with controls, all the patients with CHD had adverse serum lipid profile. However, sex hormones disorders between men and women with CHD were different:there were high P and low T levels for men but high P and low E2 levels for women.CONCLUSION The interaction among the things above might be involved in the development of CHD.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2000-07-21.
更新日期/Last Update: 2001-09-01