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钠催离及依那普利联用治疗高血压性心脏病心力衰竭(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第5期
页码:
381-382
栏目:
论著
出版日期:
2001-09-01

文章信息/Info

Title:
Treatments of combined with medication of netrilix and enapril on heart failure induced by hypertensive heart disease
作者:
孙全格1 郑强荪1 武 文2 李 博1
1. 第四军医大学唐都医院心内科, 陕西西安710038; 2. 武警山东总队医院
Author(s):
SUN Quan-ge1 ZHENG Qiang-sun1WU Wen2LI Bo1
1.Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi’an Shaanxi 710038, China
关键词:
高血压 心力衰竭 药物治疗 钠催离 依那普利
Keywords:
hypertensive heart failure treatment with drugs natrilix enapril
分类号:
R541.3; R972.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨钠催离与依那普利联用对高血压性心脏病心力衰竭的疗效及安全性。方法 联合用药组给予钠催离2.5mg, 1 次/d , 依那普利5~ 10mg, 2 次/d; 依那普利组(对照组剂量为5~ 10 mg, 2 次/d)。结果 联合用药组有效率88% , 对照组68% , 二者有显著差异(P < 0. 05)。结论 钠催离与依那普利联用对高血压性心脏病心力衰竭安全有效, 降压效果优于单用依那普利。
Abstract:
AIM To study the efficacy and sefety of combind medication of natrilix and enapril in the treatment of heart failure induced by hypertensive heart disease. METHODS For the natrilix and enapril group , the daily dose of natrilix was 2. 5 mg, once a day and that of enapril was 5 mg to 10 mg, twice a day. For the control group , enapril was given 5 mg to 10 mg, twice a day. The above treatments lasted 20 d to 30 d. RESULTS The effective rate for the former group was 88% and that for the latter was 68%. There was a striking difference (P < 0. 05) in effective rate between the two groups. CONCLUSION The combined medication is effective and safe to the treatment of heart failure induced by hypertensive heart disease, and is superior to the solifary use of enapril.

参考文献/References

[1] Pieper JA. Evolving role of calcium channel blockers in heart failure[J]. Pharmacotherapy ,1996, 16 (2) : 43S.

[2] PackerM ,O’Connor CM , Ghali JK, et al. Effect of amlodipine on morbidity in severe chronic heart failure. Prospective randomized amlodipine survival evaluation study group [J]. N Engl J Med , 1996, 335 (10) : 1107.

[3] 林善锬. 第五届国际ACEI 及其它RAS 专题讨论概要[J]. 中华心血管病杂志, 1997, 25 (4) : 321.

[4] Piepho RW. Calcium antagonist use in congestive heart failure:still a bridge too far? [J]. J Clin Pharmacol, 1995, 35 (5) : 443.

备注/Memo

备注/Memo:
收稿日期:2000-06-06.
更新日期/Last Update: 2001-09-01