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胶原和弹性纤维积聚与移植静脉桥狭窄的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第5期
页码:
388-390
栏目:
论著
出版日期:
2001-09-01

文章信息/Info

Title:
A study of correlation between stenosis of vein graft and accumulation of collagen and elastic fibers
作者:
张卫达;  朱海龙
第四军医大学西京医院心血管外科中心, 陕西西安710032
Author(s):
ZHANG Wei-da;  ZHU Hai-long
Center of Cardiovascular Surgery, Xijing Hospital Fourth Military Medical University, Xi’an Shaanxi 710032, China
关键词:
移植静脉桥;  胶原;  弹性纤维
Keywords:
vein graft;  collagen;  elastic fibers
分类号:
R654.2
DOI:
-
文献标识码:
A
摘要:
目的 研究胶原和弹性纤维分布及量的变化, 探讨其在移植静脉桥狭窄中的作用。方法 建立30 只兔自体颈外静脉移植模型, 用免疫组化和特殊染色测定胶原和弹性纤维, 计算机图像分析, 量化胶原和弹性纤维与桥壁及桥腔的关系。结果 静脉桥于术后15 d 至6 月, 胶原和弹性纤维积聚进行性增加, 增加程度与静脉桥管壁增厚和管腔缩小密切正相关。结论 胶原大量积聚可能对静脉桥狭窄起了关键作用。
Abstract:
AIM To clarity the relations between the accumulation and distribution of collagen and elastic fibers and stenosis of vein graft (VG). METHODS An auto logous jugular vein graft was transplanted into the carotid artery in 30 rabbits. The accumulation and distribution of collagen and elastic fibers were determined with immumo staining, and assayed quantitatively in VG on various points of the time. RESULTS The degrees of accumulation of collagen and elastic fibers increased are positively correlated with luminal narrowing of the VG during 1～ 6 month periods of the experiment. The more accumulation of collagen and elastic fibers occur with the greater wall thickening and luminal narrowing of VG. CONCLUSION Collagen may play a critical role in the processes of VG stenosis.

参考文献/References

[1] Atkinson JB, Forman MB, Vaughn WK, et al. Morphologic changes in long-term saphenous vein bypass grafts [J]. Chest,1985, 88: 341.

[2] Zhang WD, Bai HZ, Sawa Y, et al. Association of smooth muscle cell phenotypic modulation with extracellular matrix alteration during neointima formation in rabbit vein grafts[J]. J Vasc Surg , 1999, 30: 169.

[3] 朱海龙, 杨景学, 张卫达, 等. 实验性自体移植静脉内膜增生模型的建立[J]. 第四军医大学学报, 2000, 21: 589.

[4] Shwartz RS, Holmes DR, Topol EJ. The restenosis paradigm revistited: an aternative proposal for cellular mechanisms[J]. J Am Coll Cardiol, 1992, 20: 1284.

[5]Majors AK, Ehrhart LK. Cell density and proliferation modulate collagen synthesis and procollagen mRNA levels in arterial smooth muscle cells[J]. Exp Cell Res, 1992, 1: 168.

[6] 李　奋, 周爱卿. 弹性蛋白与肺动脉高压的肺血管重建[J]. 国外医学心血管疾病分册, 1997, 24: 20.

备注/Memo

备注/Memo:
收稿日期：2001-03-08.
更新日期/Last Update: 2001-09-01