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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2001年第6期

页码:

470-472

栏目:

论著

出版日期:

2001-11-01

文章信息/Info

Title:

An experimental study of establishing the animal model of diastolic heart failure

作者:

王　磌¹;  张　运¹;  张　薇¹;  张　梅¹;  王　勇¹;  孙文宇²;  邢艳秋¹;  张园园¹

山东医科大学附属医院: 1. 心内科, 2. 心外科, 山东济南250012

Author(s):

WANG Tian¹;  ZHANG Yun¹;  ZHANG Wei¹;  ZHANG Mei¹; WANG Yong ¹;  SUN Wen-yu²;  XING Yan-qiu¹;  ZHANG Yuan-yuan¹

1.Department of Cardiology, First Affiliated Hospital of Shandong Medical University, Ji’nan Shandong 250012, China

关键词:

心力衰竭;  舒张性;  动物模型;  心导管

Keywords:

diastolic heart failure;  animal model;  catheter Doppler echocardiography;  myocardial ischemia

分类号:

R541.6

DOI:

-

文献标识码:

A

摘要:

目的 建立舒张性心力衰竭动物模型。方法 应用心导管和超声心动图同步检查技术控制实验条件, 通过缝扎冠状动脉造成心肌缺血使左室松弛、充盈功能减低、左室舒末压升高, 而保持LV EF≥45% 的实验状态。结果 缺血即刻左室舒张末压从静息对照状态的5. 3±2. 8 mm Hg (1 mm Hg= 0. 133 kPa) 升高到711±218 mm Hg (P < 0.05) , 平均升高了3214% ±218% , 左室松驰时间常数延长, 左室舒张早期充盈速度减慢, LV EF 从57% ±6% 减少到50% ±8% (P < 0. 05)。结论 通过控制实验条件可建立舒张性心力衰竭的动物模型。

Abstract:

AIM To establish an animal model of primary diastolic heart failure. METHODS One or two branches of the left anterior descending of (LAD) of the coronary arteries were ligated completely in 10 dogs, record left ventricular pressure and left ventricular ejection fraction(LVEF) were measured by echocardiography immediately, the ischemic area of myocardium to make the left ventricular end diastolic pressure (LVEDP) rise (> 30%) and LVEF is preserved(LVEF≥45% ) , that means an animal model of prim arydiastolic heart failure of acutem yocardial ischemia is established successfully. RESULTS LVEDP increased from 5. 3±2. 8 mmHg to 7. 1±2. 8 mmHg (P < 0. 05) at myocardial ischemia with LVEF ≥45%. CONCLUSION An animal model of primary diastolic heart failure of acute myocardial ischemia can be established successfully.

参考文献/References

[1] Packer M. Abnormalities of diastolic function as a potential cause of exercise in tolerance in chronic heart failure[J]. 1990,81 (Suppl II) : II 78- 86.

[2] Pennock GD. Echocardiographic changes after myocardial infarction in a model of left ventricular diastolic dysfunction [J].Am J Physiol, 1997, 273 (4 Pt 2) : H2018- 2029.

[3] European study group on diastolic heart failure. How to diagnose diastolic heart failure [J]. Eur Heart J , 1998, 19 (7) : 990- 1003.

[4] Rick A. Evaluation of diastolic filling of left ventricular in health and disease: Doppler echocardiography is the clinician’s rosetta stone[J]. J Am Coll Cardiol, 1997, 30: 8- 18.

[5] Grossman W. Diastolic dysfunction and congestive heart failure [J]. Circulation, 1990, 81 (Suppl II) : II 1- 7.

[6] Brogan WC. The natural history of isolated left ventricular diastolic dysfunction [J]. Am J Med , 1992, 92: 627- 630.

[7] Little WC. Clinical evaluation of left ventricular diastolic performance[J]. Prog Cardiovasc Dis, 1990, 32: 273.

[8] Brutsaert DL. Relaxation and diastolic of the heart [J]. Physiol Rev, 1989, 69: 1228- 1315.

备注/Memo

备注/Memo:

收稿日期：2000-08-04. 基金项目: 卫生部临床学科重点项目基金资助[项目号16 (035) ]

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更新日期/Last Update: 2001-11-01