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|本期目录/Table of Contents|

心肌肌钙蛋白T和心肌酶谱变化与心肌损伤的关系及临床意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第1期
页码:
33-34,37
栏目:
论著
出版日期:
2002-01-01

文章信息/Info

Title:
The clinical significance of changes in serum cardiac troponin T and myocardial enzyme spectrum in myocardial injury
作者:
董解菊;  姚　磊
第三军医大学新桥医院检验科, 重庆400037
Author(s):
DONG Jie-ju;  YAO Lei
Department of Laboratory Medicine, Xinqiao Hospotal, Third Military Medical University Chongqing 400037, China
关键词:
心肌损伤;  肌钙蛋白T ;  心肌;  心肌酶谱
Keywords:
myocardial injury;  troponin T; cardiac; myocardial enzyme spectrun
分类号:
R542. 2
DOI:
-
文献标识码:
A
摘要:
目的 探讨血清心肌肌钙蛋白T(cTnT ) 和心肌酶谱在心肌损伤前后含量的变化与其临床意义。方法 动态观察20例二尖瓣瓣膜置换术(MVR)患者手术前、手术后2h及24h血清cTnT和心肌酶谱变化。另制备家兔心肌损伤模型, 检测动物模型伤前和伤后4, 8, 24h 血清cTnT的变化特点。结果 二尖瓣瓣膜置换术患者血清cTnT 含量、心肌酶谱活性在术后2, 24h 较术前显著升高(P<0.01) , 其中血清cTnT含量术后2h 增加倍数高于其他指标。家兔心肌损伤模型伤后4, 8, 24h 血清cTnT含量较伤前升高非常显著(P<0.01)。结果 血清cTnT含量及心肌酶谱活性均对心肌损伤的诊断有意义,cTnT的心肌特异性及早期灵敏度更高。
Abstract:
AIM To evaluate the clinical signifcance of changes in serum cardiac tropon in T (cTnT )and myocardial enzyme spectrum in myocardial injury. METHODS In twenty patients who underwent mitral valve replacement (MVR) , serum cTnT and myocardial enzyme spectrum levels were measured before the operation and 2 and 24 hours after the operation. Rabbit myocardial injury model was established to detect the changes of serum cTnT before the operation and 4, 8 and 24 hours after the operation. RESULTS Compared with patients before MVR operation , the serum cTnT and the myocardial enzyme spectrum levels at 2 and 24 hours after MVR operation increased significantly (P < 0. 01) , and the serum cTnT concent rations at 2 hours after the operation increased times more than other indexes. In rabbit myocardial injury models, the serum cTnT concent rations at 4. 8 and 24 hours after injury were significantly higher than those before the injury (P < 0. 01). CONCLUSION Both the serum cTnT the myocardial enzyme spectrum levels could serve as useful markers to reflect myocardial injury, but cTnT appears to be more specific and sensitive than the myocardial enzyme spectrum.

参考文献/References

[1]Mercier P, Li MX, Sykes BD. Role of the structural domain of troponin C in muscle regulation: NMR studies of Ca2+ binding and subsequent interactions with regions 1-40 and 96-115 of troponin I[J]. Biochemistry , 2000, 39 (11) : 2902- 2911.

[2] Hawkins RC, Tan HL. Comparison of the diagnostic utility of CK, CK-MB (activity and mass) , troponin T and troponin I in patients with suspected acute myocardial infarction [J].Singapore Med J , 1999, 40 (11) : 680- 684.

[3] Wu AH,Abbas SA , Green S, et al. Prognostic value of cardiac troponin T in unstable angina pectoris[J]. Am J Cardiol, 1995,76: 970- 972.

[4] Banerjee HN ,VermaM , Hou LH, et al. Cytoxicity of TNT and its metabolites[J]. Yale J Biol Med , 1999, 72 (1) : 1- 4.

[5] Farah CS, Reinach FC. The troponin complex and regulation of muscle contraction[J]. FASEB J , 1995, 9 (4) : 755- 759.

[6] Chandra M , Montgomery DE, Kim JJ , et al. The N-terminal region of troponin T is essential for themaximal activation of ratcardiac myofilaments[J].J Mol Cell Cardiol, 1999, 31 (4) : 867- 880.

[7] Gerhardt W ,Nordin G,Ljungdahl L. Can troponin T replace CK MBmass as " gold standard" for actue myocardial infarction ("AMI" ) ? [J]. Scand J Clin Lab Invest Suppl, 1999, 230 (1) : 83-89.

备注/Memo

备注/Memo:
收稿日期：2000-07-24.
更新日期/Last Update: 2002-01-01