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他汀类药物与细胞增殖性心血管疾病的关系的研究现状(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第2期
页码:
162-164
栏目:
综述
出版日期:
2002-03-01

文章信息/Info

Title:
-
作者:
徐　琳;  赵连友 综述
第四军医大学唐都医院心内科, 陕西 西安 710038
Author(s):
-
关键词:
他汀类药物;  细胞增殖;  心血管疾病
Keywords:
-
分类号:
R972.6
DOI:
-
文献标识码:
A
摘要:
作者综述了他汀类药物的作用及其机制, 重点概述了它与高血压病、动脉粥样硬化和经皮腔内冠状动脉成形术后再狭窄的关系。
Abstract:
-

参考文献/References

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[4] Guijarro C, Blanco-Colio LM, Ortego M,et al.3-hydroxy-3-methylglutaryl coenzyme A reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture [J].Circ Res,1998,83:490-500.

[5] Kano H, Hayashi T, Sumi D,et al. A HMGCoA reductase inhibitor improved regression of atherosclerosis in the rabbit aorta without affecting serum lipid levels: possible relevance of upregulation of endothelial NO Synthase mRNA [J].Biochem Biophys Res Commu, 1999,259:414-419.

[6] Bellosta S, Via D, Canavesi M,et al. HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages [J].Arterioscle Thromb Vasc Biol, 1998,18:1671-1678.

[7] Vrtovsnik F, Couettes, Prie D,et al. Lovastatin inhibition of renal epithelial tubular cell proliferation involves a P21ras activated AP-1-dependent pathway[J].Kidney Int, 1997,52:1016-1027.

[8] Narisawa J, Morotomi M, Fukaura Y,et al. Chemoprevention by HMG-CoA reductase inhibitor of N-methyl-N-nitrosoureg induced colon carcinogenesis in F344 Rats[J].Jpn J Cancer Res, 1996,87:798-804.

[9] Bellosta S, Bernini F, Ferri N,et al. Direct vascular effects of HMG-CoA reductase inhibitor[J].Atherosclerosis, 1998,137:s101-s109.

[10] Corsini A, Pazzucconi F, Arnaboldi L,et al. Direct of Effects of statins on the Vascular Wall [J].J Cardiovasc Pharmacol,1998,31:773-778.

[11] Laufs U, Fata VL, Plutzky J,et al. Upregulation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors [J].Circulation, 1998,97:1129-1135.

备注/Memo

备注/Memo:
收稿日期：2001-10-24.
更新日期/Last Update: 2002-03-01