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哌仑西平对兔急性心肌缺血心室颤动阈值的影响及其机制(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第3期
页码:
204-207
栏目:
实验研究
出版日期:
2002-05-01

文章信息/Info

Title:
Effect of pirenzeine on the ventricular fibrillation threshold during acute myocardial ischemia in rabbits and itsmechanism
作者:
方　昶;  张旭明;  伍　卫;  王景峰;  张　燕
中山医科大学孙逸仙纪念医院心电生理室, 广东 广州 510120
Author(s):
FANG Chang ;  ZHANG Xu-ming ; WU Wei; WANG Jing-feng ;  ZHANG Yan
Sun Yet-sen Memorial Hospital, Guangzhou Guangdong 510120, China
关键词:
哌仑西平;  心肌缺血;  阈值;  阈值;  心室颤动;  心率变异性;  迷走神经切断术;  交感神经化学切除
Keywords:
pirenzepine;  myocardial ischemia;  acute;  ventrcular fibrillation threshold;  heart ratevariability;  vagotomy;  chemial sympathectomy
分类号:
R540.41;R541.7　　
DOI:
-
文献标识码:
A
摘要:
目的 观察小剂量哌仑西平对兔急性心肌缺血心室颤动阈值的影响。探讨自主神经作用及其机制。方法 建立兔急性心肌缺血模型。采用颈迷走神经切断术、心脏交感神经化学切割技术建立不同自主神经支配的心脏模型。以心率变异频域指标测定心脏自主神经活性, 应用心电生理研究方法测定急性心肌缺血心室颤动阈值(VFT)。结果 兔急性心肌缺血时, 哌仑西平预处理组较单纯结扎组频域指标VLF, LF 与LF/HF 降低, HF 增高; 电生理指标VFT 增高。颈迷走神经切断后, 急性心肌缺血时, 哌仑西平预处理组较单纯结扎组频域指标VLF,LF,LF/HF 降低,HF 无显著变化,VFT 增加。心脏交感神经化学切除后, 急性心肌缺血时, 哌仑西平预处理组较单纯结扎组频域指标VL F,LF,LF/HF 降低, HF 增加,VFT 增大。结论 小剂量哌仑西平预处理能改善兔急性心肌缺血时的心电生理不稳定状态。此作用与直接降低心脏交感神经活性及直接提高心脏迷走神经活性有关。
Abstract:
AIM To observe the effect of low dose pirenzepine (PZP) on the ventricular fibrillation threshold(VFT) in myocardial ischemia model of rabbits and its mechanism.METHODS In the model,VFT was measured with electrophysiological methods and the power domain parameters of heart rate variability (HRV) including VLF,LF,HF and LF/HF were assessed. The activity of cardiac autonomic nervous sytem was changed by vagotomy and chemical sympathectomy.RESULTS When acute myocardial ischemia haeppened,in PZP pretreatment group,compared with the single ligation group,VLF,LF and LF/HF decreased;HF increased and VFT increased. With cervical vagotomy,when acute myocardial ischemia happened,in PZP pretreatment group, compared with the single ligation group,VLF,LF and LF/HF decreased;HF did not changed and VFT increased. With cardiac sympathectomy,when acute myocardial ischemia happened,in PZP pretreatment group,compared with the single ligation group,VLF,LF and HF/HF decreased;HF increased and VFT increased.CONCLUSION The pretreatment of low dose PZP enhanced the cardiac electrical stability in acute myocardial ischemia through decreasing cardiac sympathetic activity directly and increasing cardiac parasympathetic activity directly.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期: 2001-06-06.基金项目: 广州市科委科技攻关项目资助(97-Z-48-09)
更新日期/Last Update: 2005-05-01