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|本期目录/Table of Contents|

充血性心力衰竭患者可溶性细胞间粘附分子21 检测的临床意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第3期
页码:
245-246,249
栏目:
临床研究
出版日期:
2002-05-01

文章信息/Info

Title:
Clinical significance of decting soluble intercellular adhision molecule-1 in patients with congestive heart failure
作者:
李慧芳1;  王晓明2;  韩善润3;  李　源2
1.武警山西总队医院内三科, 山西 太原 030006; 2.第四军医大学西京医院老年病科; 3.陕西省军区门诊部
Author(s):
LI Hui-fang ; WANG Xiao-ming ;  HAN Shan-run;  LI Yuan
Department of in ternal medicine, Shanxi Corps Hospital, Chinese Peoples Armed Police,Taiyuan, Shanxi 0300063, China
关键词:
心力衰竭;  充血性;  细胞粘附分子
Keywords:
heart failure;  congestive;  soluble in tercellular adhesion molecule-1
分类号:
R541.61; R392.11
DOI:
-
文献标识码:
A
摘要:
目的 探讨充血性心力衰竭(CHF) 患者血清可溶性细胞间粘附分子21( sICAM 21) 的水平与CHF 患者心功能状态的关系。方法 采用酶联免疫吸附法(ELISA ) 检测84 例CHF 患者sICAM 21 水平并与30 例健康人作对照, 通过彩色多普勒超声心动图测定CHF 患者左室射血分数(LVEF 值)。结果 ①CHF 患者sICAM 21 水平(588±152 Lg·L - 1) 较对照组(167±35 Lg·L - 1) 明显升高, 有显著性差异(P < 0. 01)。②sICAM 21 水平随着心功能不全的加重而升高, 心功能? 级患者高于心功能Ⅱ , Ⅱ级患者(P < 0. 05) , ③ LVEF 值和sICAM 21 水平, 两者呈显著的负相关(r=- 0155, P < 0. 01)。结论 sICAM 21 在CHF 的发病机制中起重要作用, sICAM 21 水平可能是CHF 患者心功能程度判定和疗效观察的有价值的检测指标。
Abstract:
AIM To investigate the serum concentration of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with congestive heart failure(CHF)and the relationship between sICAM-1 and their cardiac function.METHODS The serum level of sICAM-1 was determined with enzyme-linked immunosorbent assay in 84 patients with CHF and 30 healthy individuals(control group). Left ventricular ejection fraction (LVEF) in patients with CHF was measured by colour Dopper echocardiography.RESULTS The serum levels of sICAM-1 in patients with CHF were significantly higher than those in controls(P<0.01). The serum levels of sICAM-1 have significant increased with the decrease of heart function. The serum levels of sICAM-1 in classⅣpatients with CHF were higher than those in classⅡandⅢ(P<0.05). Serum levels of sICAM-1 negatively correlated to LVEF (r=-0.55,P<0.01).CONCLUSION sICAM-1 plays an important role in the pathogenesis of CHF. The serum level of sICAM-1 may be important parameter for heart function degree determination and therapy effect observation in patients with CHF.

参考文献/References

[1] Katz AM. Regression of left ventricular hypertrophy: new hope for dying heart[J].Circulation,1998,98:623-624.

[2] Sharma R, Coats AJ, Anker SD. The role of inflammatory mediators in chronic heart failure:cytokines,nitric oxide,and endothelin-1[J].Int J Cardiol,2000,72(2):175-186.

[3] Bevilacqua MP. Endothelial-leukocyte adhesion molecules[J].Annu Rec Immunol, 1993,11:767-804.

[4] Devanx B, Scholz D, Hirche A,et al. Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure[J]. Eur Heart J, 1997,18: 470-479

[5] Tousoulis D, Homaei H, Ahmed N,et al. Increased plasma adhesion molecule levels in patients with heart failure who have ischemic heart disease and dilated cardiomyopathy[J].Am Heart J, 2001, 141(2):277-280.

[6] Smith CW, Entman ML, Lane CL,et al. Adherence of neutrophils to canine cardiac myocytes in vitro is dependent on intercellular adhesion molecule-1[J].J Clin Invest, 1991, 88:1216-1223.

备注/Memo

备注/Memo:
收稿日期：2001-12-22.
更新日期/Last Update: 2005-05-01