全反式维甲酸对大鼠腹主动脉球囊损伤后内膜增生的影响(PDF)
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2002年第4期
- 页码:
- 284-286
- 栏目:
- 实验研究
- 出版日期:
- 2002-07-01
文章信息/Info
- Title:
- Effect of all- trans retinoic acid on intimal hyperplasia in rat abdominal artery with balloon withdrawa linjury
- Author(s):
- DANG Shu-yi1; WANG Jia-ning1; HUANG Yong-zhang2; WANG Wei-min2; CHEN Xia-ping22; LIU Zhi-xiang2; ZHOU Fang2; ZHANG Qun-lin1
- 1.Department of Cardiology and Institute of life sciences, Tai he Hospital, Yunyang Medical College, Sh yan, Hubei 442000, China
- Keywords:
- all-trans retinoic acid; intimal hyperplasia; cell; smooth muscle; vascula
- 分类号:
- Q562
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的 研究全反式维甲酸(ATRA ) 对球囊损伤大鼠腹主动脉内膜增生的影响。方法 制作球囊损伤的大鼠腹主动脉剥脱模型,Wistar 大鼠12 只随机分为①对照组(n= 6) : 腹腔内注射int ralip id (1 m l?d) , ②A TRA 组(n= 6) :腹腔内注射溶解于intralipid 的ATRA (4mg·kg- 1·d- 1)。球囊损伤14 d 后, 损伤区域的血管段用40 g/L 甲醛固定, 然后染色, 进行组织学观察和形态学分析。结果 ATRA 明显减小新生内膜面积, 增加管腔面积。结论 ATRA具有抑制损伤血管内膜增生的作用。
- Abstract:
- AIM To investigate the effect of all-trans retinoic acid(ATRA) on intimal hyperplasia after balloon withdrawal injury in the rat abdominal artery. METHODS The rat denuded abdominal artery model with balloon withdrawal injury was performed. Twelve Wistar rats were randomly divided into①Control group:intraperitoneal injection of intralipid(1 ml/d);②ATRA group:intraperitoneal injection of ATRA dissolved in intralipid(4 mg·kg-1·d-1). Fourteen days after the balloon withdrawal injury in situ perfusion fixation was performed with 40 g/L methylal and the specimens were obtained. Histologic observations and morphometric analyses were performed.RESULTS ATRA significantly reduced the neointimal area and increased the lumen-area.CONCLUSION ATRA has inhibited intimal hyperplasia of injuried vascula.
参考文献/References
[1] Fischman D,Leon M,Baim D,et al. A randomized comparison of coronary stent placement and balloon angioplasty in the treatment of coronary disease[J].N Engl J Med,1994,331:496-501.
[2] Robert S, Schwartz MD. Pathophysiology of retenosis:interaction of thrombosis hyperplasia and/or remodeling[J].Am J Cardiol,1998,81(7A):14E-17E.
[3] Lee CW, Park SJ, Park SW,et al. All-trans-retinoic acid attenuates formation with aceeleration of reendothelialization in balloon-injured rat aorta[J].J Korean Med Sci,2000,15:31-36.
[4] Van Giezen JJ,Boon GI,Jansen JW,et al. Retinoic acid enhances fibrinolytic activity in-vivo by enhancing tissue type plasminogen activator ( t-PA) activity and inhibits venous thrombosis[J].Thromb Haemost,1993,69:381-386.
[5] Takatsuka J, Takahashi N, Deluca LM. Retinoic acid metabolism and inhibition of cell proliferation:an unexpected liaison[J]. Cancer Res,1996,56:675-678.
[6] Mukherjee G,Ghatterjee GC. Differential effect of retinoic acid on ADP and collagen induced platelet aggregation[J].Indian J Exp Med,1990, 28:949-952.
[7] Gillie J,Paxton LL,Lawley JJ,et al. Retinoic acid inhibits the regulated expression of vascular cell adhesion molecule-1 by cultured dermal microvascular endothelial cells [J].J Clin Invest,1997,99:492-500.
[8] Miao JM,Majesky MW,Topouzis S,et al. Retionid receptor expression and all-trans retinoic acid-mediated growth inhibition in vascular smooth muscle cells[J].Circulation,1996,93:1886 -1895.
[9] Zempo N, Kenagy RD, Bendeck M,et al. Matrix metall-oprteinases of vascular wall cells are increased in ballon-injured rat carotid artery[J].J Vasc Surg,1994,20:209-214.
[10]James TW,Wangner R,White LA. Induction of collagenase and stromelys in gene expression by mechanical injury in a vascular smooth muscle-derived cell line[J].J Cell Physiol, 1993,157:426-437.
[11] Nagy L, Thomazy VA, Chandraratna R,et al. Retinoid-regulated expression of bcl-2 and tissue trans-glutaminase during the differentiation and apoptosis of human and apoptosis of human myeloid Leukemia(HL-60) Cells[J].Leuk Res,1996,20:499-505.
备注/Memo
- 备注/Memo:
- 收稿日期：2001-04-09.基金项目: 湖北省科委资助课题(991B28) ; 湖北省十堰市科委资助课题(99D011)
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