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|本期目录/Table of Contents|

不稳定型心绞痛患者白细胞CD_(1b)/CD_(18)表达的变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第4期
页码:
310-311
栏目:
临床研究
出版日期:
2002-07-01

文章信息/Info

Title:
The expression of leukocyte adhesion molecules CD11b/CD18in patients with unstable angina pectoris
作者:
张玉顺1;  扎 拥2;  张进虎3;  贾国良1
1.第四军医大学西京医院心内科,陕西西安710032;2.武警西藏总队医院;3.西安第四职工医院
Author(s):
ZHANG Yu-shun; ZA Yong; ZHANG Jin-hu; JIA Guo-liang
Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi′an,Shaanxi 710032,China
关键词:
心绞痛; 白细胞; 细胞粘附分子
Keywords:
angina pectoris; leukocyte; adhesion molecule
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察不稳定型心绞痛患者中性粒细胞和单核细胞膜CD11b/Cd18表达的变化。方法 选择经冠状动脉造影确诊的不稳定型心绞痛32例和正常人20例,用流式细胞仪直接免疫荧光法检测中性粒细胞和单核细胞膜CD11b/CD18表达。结果 不稳定型心绞痛患者中性粒细胞和单核细胞膜CD11b/CD18表达较正常对照组均显著增加(P<0.01);且CD11b/CD18表达的增加与心绞痛的发作有关,而与冠状动脉狭窄程度和病变支数无关。结论 不稳定型心绞痛患者中性粒细胞和单核细胞膜CD11b/CD18表达明显增加,其增加程度与心绞痛的发作有关。
Abstract:
AIM To investigate the changes in the expression of adhesion molecules CD11b/CD18on neutrophils and monocytes in patients with unstable angina pectoris(UAP).METHODS The expression of adhesion molecules CD11b/CD18on neutrophils and monocytes was dected by direct immunofluorescence techniques associated with flow cytometry in 32 UAP to be proved by coronary arteriography, and 20 normal cases.RESULTS The expression of CD11b/CD18of neutrophils and monocytes in patients was markedly higher than that in normal cases(P<0.01). The increased expression of adhesion molecules CD11b/CD18on neutrophils and monocytes in the UAP patients was related to angina pectoris seizure,but had no relation to severity of coronary stenosis.CONCLUSION CD11b/CD18expression on neutrophil and monocyte in UAP patients increase obviously,and that the increased degree is related to seizure of angina episodes.

参考文献/References

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[3] 张玉顺,张进虎,扎 拥,等.冠心病患者中性粒细胞和单核细胞CD11B/CD18表达的研究[J].心脏杂志,2001,13(1):13-15.

[4] De servi S,Mazzone A,Ricevuti G,et al. Clinical angiographic corrleates of leukocyte activation in unstable angina[J].J Am Coll Cardiol,1995,6:1146-1150.

[5] Davies MJ,Gordon JL,Gearing JH,et al. The expression of the adhesion molecules ICAM-1 VCAM-1,PECAM, and E-selectin in human atherosclerosis[J].J Pathol,1993,171:223-229.

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备注/Memo

备注/Memo:
收稿日期：2001-05-17.
更新日期/Last Update: 2002-07-01