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血管内超声探测冠状动脉病变与其危险因素的关联性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第2期
页码:
155-157
栏目:
影像学
出版日期:
2003-03-01

文章信息/Info

Title:
Association of risk factors of coronaryartery disease and coronary artery lesion with an intravascular ultrasound study
作者:
王冬梅; 韩雅玲; 王守力; 刘莹; 荆全民; 苗志林; 王祖禄
沈阳军区总医院心内科,辽宁 沈阳 110016
Author(s):
WANG Dong-mei; HAN Ya-ling; WANG Shou-li; LIU Ying; JING Quan-min; MIAO Zhi-lin;  WANG Zu-lu
Department of Cardiology,General Hospital of PLA Shen yang Command,Shen yang,Liao ning 110016,China
关键词:
超声检查术; 冠状动脉疾病; 危险因素
Keywords:
ultrasonography; coronary disease; risk factor
分类号:
R445.1
DOI:
-
文献标识码:
A
摘要:
目的:通过血管内超声(IVUS)观察冠状动脉病变与冠心病(CHD)危险因素的关系。方法:根据是否伴CHD 危险因素分无危险因素患者40例;伴CHD危险因素患者104例,再将伴CHD危险因素患者按血管狭窄程度分狭 窄<75%组43例,狭窄≥75%组61例。所有患者均行冠状动脉造影(CAG)及IVUS检查。结果:①狭窄<75%组、 狭窄≥75%组与无危险因素组比病程短,且血管狭窄≥75%组病程更短(P<0.05),不稳定型心绞痛及急性心肌梗 死发病率高。②狭窄≥75%组的血管病变长度较无危险因素组及狭窄<75%组明显延长(均P<0.01)。③狭窄≥ 75%组多为脂质性及偏心性斑块,无危险因素组则以纤维性及同心性斑块为主。④狭窄<75%组、狭窄≥75%组可 见明显的正性血管重构,多于无危险因素组。狭窄≥75%组比狭窄<75%组有更多的负性血管重构。结论:CHD伴 危险因素患者,CHD的病程短、进展快,冠状动脉病变不稳定,有明显的血管重构,正性重构以软斑块为主,此时冠 状动脉内血栓和斑块破裂现象也更多见。负性重构则加速斑块生长导致管腔严重狭窄。
Abstract:
AIM:To assess the correlation between coronaryartery lesion and risk factors for coronary artery desease(CAD).METHODS:One hundred and forty-four patients were studied by coronary angiography(CAG) and intravascular ultrasound(IVUS).According to the absence and presence of risk factors,40 patients were grouped as non-risk-factor group and 104 as risk factor group. Then according to the narrowing degree of blood vessel,patients in risk-factor group were subdivided into groupA (n=43,stenosis<75%) and groupB (n=61,stenosis≥75%).RESULTS:①The disease history of the two risk-factor group was shorter than that of the non-risk-factor group, and that of group B was the shorfest.The incidence of unstable angina pectoris and AMI was higher.②The length of the lesion in group B was 25mm(P<0.01),which was apparently longer compared with those of then on-risk-factor group(14mm)and groupA(13mm).③In group B,concentric plaques and lipid plaques were of ten found,while in the non-risk factor group, concentric plaques and fibril plaques were usually seen(P<0.05).④Positive vessel remodeling was more significant in the risk-factor group than in the non-risk factor group. More negative remodelings occurred in group B than in group A.CONCLUSION: CAD patients with risk factors tend to have a quicker attack and faster progress of the disease.The pathological changes are unstable, and there is obvious vesselre modeling. Soft plaques are more commonly seen in positive vesselre modeling.Meanwhile coronary thrombosis and plaque rupture are more common

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2002-6-6.
更新日期/Last Update: 2003-03-01