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|本期目录/Table of Contents|

血红素氧化酶-1对心脏的保护作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第4期
页码:
375-377
栏目:
综述
出版日期:
2003-07-01

文章信息/Info

Title:
-
作者:
杨萍萍1 综述; 袁文俊2 审校
第二军医大学:1.学员一旅,2.生理学教研室,上海 200433
Author(s):
-
关键词:
血红素氧化酶-1; 心脏保护; 细胞保护
Keywords:
-
分类号:
Q554.9
DOI:
-
文献标识码:
A
摘要:
血红素氧化酶(HO)是一种作用很强的内源性调节分子,多种疾病如急性肾衰、动脉粥样硬化、缺血性心肌损害时HO-1的表达增多。本文就此及其机制进行了综述。
Abstract:
-

参考文献/References

[1] Yachie A, Niida Y, Wada T, et al. oxidative stress causes enhanced endothelial cell injury inhuman hemeoxy genase-1 deficiency [J] . J ClinInvest, 1999, 103:129-135.

[2] Schipper HM, Chertkow H, Mehindate K, et al. Evaluation of hemeoxy genase-1 as a systemic biological marker of sporadic AD [J] . Neurology, 2000, 54:1297-1304.

[3] Paredi P, Biernacki W, Invernizzi G, et al. Exhaled carbon monoxide levels elevated in diabetes and correlated with glucose concentration in blood: a new test for monitoring the disease? [J] . Chest, 1999, 116:1007-1111.

[4] Yer SF, Perrella MA, Layne MD, et al. Hypoxia inducie severe right ventricular dilatation and infarction in heme oxygenase-1 mull mice [J] . J Clin Invest, 1999, 103:23-29.

[5] Yet SF, Tian R, Layne MD, et al, Perrella Mal Cardiac specific expression of hemeoxygenase-1 protects against ischemia and reperfusion injury intransgenic mice [J] . Circ Res, 2001, 89:168-173.

[6] Hangaishi M, Ishizaka N, Aizawa T, et al. Induction of hemeoxy genase-1 can act protectively against cardiac ischemia/reperfusion in vivo [J] . Biochem Biophys Res Commun,2000, 279:582-588.

[7] Clark JE, Foresti R, Sarathchandra P, et al. Hemeoxygenase-1-derived bilirubin ameliorates post ischemic myocardial dysfunction [J] . Am J Physiol, 2000, 278:H643-H651.

[8] Christou H, Morita T, Hsieh CM, et al. Prevention of hypoxia induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat [J] . Circ Res, 2001, 86:1224-1229.

[9] Sato K, Balla J, Otterbein L, et al. Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants [J] . J Immunol, 2001, 166:4185-4194.

[10] Dore S, Takahashi M, Ferris CD, et al. Bili rubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury [J] . Proc Nall Acad Sci USA, 1999, 6:2445-2450.

[11] Chen K, Gunter K, Maines MD. Neurons over expressing heme oxygenase-1 resist oxidative stress-mediated cell death [J] . J Neurochem, 2000, 75:304-313.

[12] Platt JL, Nath KA. Heme oxygenase: proliferation [J] . Nat Med, 2001, 7:693-699.

[13] Otterbein LE, Bach FH, Alam J, et al. Carbon monoxide mediates anti-inflammatory effects via the p38 mitogen activated protein kinase pathway [J] . Nat Med, 2000, 6:422-428.

[14] Fujita T, Toda K, Karimova A, et al. Paradoxical rescue from ischemic lung injury by in haled carbon, monoxide driven by derepression of fibrinolysis [J] . Nat Med, 2001, 7:598-604.

[15] Duckers HJ, Boehm M, True AL, et al. Heme oxygenase-1 protects against vascular constriction and proliferation [J] . Nat Med, 2001, 7:693-699.

[16] Foresti R, Motterlini R. The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis [J] . Free Radic Res, 1999, 31:459-457.

备注/Memo

备注/Memo:
收稿日期：2002-05-31.
更新日期/Last Update: 2003-07-01