我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

跨室壁复极离散度变化对心电图T 波形态影响的电生理研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第5期
页码:
406-409
栏目:
实验研究
出版日期:
2003-09-01

文章信息/Info

Title:
The research of the variation in transmural dispersion of repolarization and its effect on T-wave in ECG in vivo
作者:
龚志刚1; 苏东东2; 黄从新1; 江洪1; 赵庆彦1
1.武汉大学人民医院心内科, 湖北 武汉 430060; 2.武汉总医院门诊部,湖北 武汉 430070
Author(s):
GONG Zhi-gang1;  SU Dong-dong2;  HUANG Cong-xin1;  JIANG Hong1;  ZHAO Qing-yan1
1.Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, Hubei 430060, China; 2.Out patient Department, Wuhan General Hospital, Wuhan, Hubei 430070, China
关键词:
跨壁复极离散度; 单相动作电位; 心室肌; T波
Keywords:
transmural dispersion of repolarization;  monophasic action potential;  ventricular myocardium;  T wave
分类号:
Q424; R540.41
DOI:
-
文献标识码:
A
摘要:
目的:探讨在体情况下心肌跨室壁复极离散度(TDR) 变化对心电图T 波影响的可能机制。方法: 运用单相动作电位(MAP)记录技术,同步记录14只开胸兔的左室心肌心外膜层(Epi),中层(Mid),内膜层(Endo)的MAP,分别予以静脉注射索他洛尔(dl-sotalol),海葵毒素(ATX-II)后,观察跨室壁复极离散的变化及同时心电图T 波的相应改变。结果:①dl-sotalol导致Mid层细胞MAP的复极时间(RT)显著的延长(从202±19 ms到395±34ms),TDR增大(从11±4ms到75±25ms),Q T间期延长(从208±16ms到397±33ms),3层心肌MAP的3相复极不同程度的延长,使复极电位梯度变化,产生增宽、低幅有切迹的T波。②ATX-II 导致M id 层细胞MA P 的RT 显著的延长(从370±34 m s 到473±35 m s) , TDR 增大(从40±21 m s 到62±19 m s) ,Q T 间期延长(从372±33 m s到479±33ms),3层心肌MAP的2相平台期不同程度延长,使复极电位梯度变化,产生晚现T波,波幅增大。结论:在体兔心肌跨壁复极离散度的变化对心电图T波的形态有重要影响。
Abstract:
AIM: To investigate the variation in transmural dispersion of repolarization and its effect on T-wave in ECG in vivo. METHODS: With the monophasic action potential (MAP) recording technique, MAPs of epicardium, midmyocardium and endocardium were recorded by specially designed plung-needle elect rodes at the left ventricular myocardium in 14 open-chest rabbits. After in travenous inject ion of dl-sotalol and A TX-II respectively, variation in transmural dispersion of repolarization on three myocardial layers and T-wave in ECG were investigated. RESULTS: ①dl-sotalo l caused a preferential prolongation of the Mid-cell repolarization time (RT , 202±19ms to 395±34ms), giving rise to broad and some times low amplitiude bifurcated T waves, and increased TDR (11±4 ms to 75±25 ms) and Q T in terval (208±16 ms to 397±33 ms) ; ②A TX-II caused preferential prolongation of the Mid-cell RT (370±34 ms to 395±34 ms) , a marked delay in the onset of the T waves, a sharp rise in TDR (40±21 ms to 62±19 ms) and Q T in terval 372±33 ms to 479±33 ms). CONCLUSION: The variation in transmural dispersion of repo arization of vent ricular myocardium has important effects on the T wave of ECG in vivo of the rabbit.

参考文献/References

[1] 臧益民, 臧伟进. M细胞、跨室壁离散度与心律失常的关系 [J] . 心脏杂志, 2002, 14(4):343-345.

[2] Yan GX. Cellular basis for the normal T wave and the electrocardiog-raphic manifestations of the long Q T syndrome [J] . Circulation, 1998, 98: 1928.

[3] 杨天骄, 马业新, 肖建民, 等. 犬在体心肌跨室壁复极不均一性的研究 [J] . 中华心血管病杂志, 2002, 30: 239.

[4] Antzelevitch C. Heterogeneity with in the ventricular wall [J] . Circ R es, 1991, 69: 1427.

[5] Antzelevitch C. The M cell: contribution to the ECG and to normal and abnormal electrical function of the heart [J] . Cardiovasc Electrophysiol, 1999, l0:1125.

[6] Shimizu W , Antzelevitch C, Sicouri S, et al. Cellular basis for the ECG features of the long Q T syndrome [J] . Circulation, 1998, 24: 2314.

备注/Memo

备注/Memo:
收稿日期：2002-09-19
更新日期/Last Update: 2003-09-01