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卡维地洛和培哚普利对急性心肌梗死后心功能改善的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第5期
页码:
457-458
栏目:
影像学
出版日期:
2003-09-01

文章信息/Info

Title:
Effect of Carvedilol and Perindopril on cardiac function of patients with heart failure after acute myocardial infarction
作者:
石玉1; 杨继庆2; 张三奇1; 周晓东3; 杨勇4; 程康4
第四军医大学:1.西京医院药剂科,2.物理学教研室,3.西京医院超声科,4.西京医院心脏内科,陕西 西安 710032
Author(s):
SHI Yu1;  YANG Ji-qing2;  ZHANG San-qi1;  ZHOU Xiao-dong3;  YANG Yong4;  CHENG Kang4
1.Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China
关键词:
卡维地洛; 培哚普利; 心肌梗塞; 急性; 心功能
Keywords:
Carvedilol;  Perindopril;  infarction;  acute;  cardiac function
分类号:
R972.2;R541.4
DOI:
-
文献标识码:
A
摘要:
目的:观测卡维地洛和培哚普利对急性心肌梗死后心功能的影响。方法:急性心梗后心功能不全住院患者62例。随机分成2组先分别给予卡维地洛及培哚普利治疗3月,然后再联合治疗3月后复查超声心动图测定左室能。结果:①单用卡维地洛或培哚普利均可显著降低左室收缩末期容积(LVESV),左室射血分数(LVEF)明显增加,左室充盈早期血流传播速度(LVFPS)明显加快。②两药联用后LVESV,LVEF及LVFPS较单用药组有显著性变化。结论:卡维地洛和培哚普利可明显改善急性心梗后心功能不全患者左心功能。
Abstract:
AIM: To observe the effect of Carvedilol and Perindopril on cardiac function of patients with heart failure after acute myocardial infarction. METHODS: 62 in patients with heart failure after acute myocardial infarction were randomized into Carvedilol group and Perindopril group in the first 3 months, and then treated with the combination of Carvedilol and Perindopril. The left ventricular function of these patients was measured by echocardiography at the beginning and at the end of the test respectively. RESULTS:①Carvedilol or Perindoprilal one could reduce the left ventricular end systole volume (LVESV) and increase the left ventricular ejection fraction (LVEF) significantly, and the left ventricular filling propagations lope (LVFPS) becomes faster.②The changes of LVESV, LVEF and LVFPS were more significant when patients were treated with the combination of the two drugs than with either alone of them. CONCLUSION: There is a significant effect of Carvedilol and Perindoprilon cardiac function of patients with acute myocardial infarction.

参考文献/References

[1] 臧益民, 臧伟进, 王晓明. 心力衰竭的病理生理机制及治疗概述 [J] . 心脏杂志, 2002, 14(5):417-419.

[2] Dargie HJ. Effect of carvedilol on outcome after myocardial infarction in patients with left ventricular dysfunction: the CAPPICORN randomissed trial [J] . Lancet, 2001, 357:1385.

[3] Kurrelmeyer K, Kalra D, Bozkurt B, et al. Cardiac remodeling as a consequence and cause of progressive heart failure [J] . Clin Cardiol, 1998, 21(Suppl1):14.

[4] 董少红. 左心室局部收缩及舒张不协调性对左心室整体舒张功能的影响 [J] . 心功能杂志, 1999, 11(4):225.

[5] 侯云生, 何国祥, 何振山, 等.黄芪对急性心肌梗死后左室重构的治疗作用 [J] . 心脏杂志, 2000, 12(4):270.

备注/Memo

备注/Memo:
收稿日期：2002-11-14.
更新日期/Last Update: 2003-09-01