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冠心病患者血浆神经肽Y与心率变异性的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第6期
页码:
530-531
栏目:
临床研究
出版日期:
2003-11-01

文章信息/Info

Title:
The Relationship between neuropeptide Y and heart rate variability in patients with coronary artery disease
作者:
马志强; 成蓓; 王毅; 狄明
华中科技大学同济医学院心血管病研究所, 湖北 武汉 430022
Author(s):
MA Zhi-qiang;  CHENG Bei;  WANG Yi;  DI Ming
Institute of Cardiovascular Diseases, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
关键词:
冠状动脉疾病; 神经肽Y; 心率变异性
Keywords:
neuropeptide y;  coronary disease;  heart rate variability
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:探讨冠心病患者血浆神经肽Y(NPY)含量与心率变异性(HRV)的关系。方法: 随机选择25例冠心病患者和27例健康志愿者作24h动态心电图并做HRV分析, 同时测定其空腹血浆NPY浓度。结果:与健康人比较, 冠心病患者SDNN, SDANN , HF,LF 显著下降, LF/HF和血浆NPY显著上升,NPY 与HF,LF,LF/H F 呈明显相关性(r=-0.9, P<0.01; r=- 0.6, P<0.05; r=0.9, P<0.05)。结论: 冠心病患者血浆NPY与HRV 密切相关。
Abstract:
AIM: To investgate the relation between plasmaneuropeptide Y (NPY) and heart rate variability in patients with coronary artery disease (CAD). METHODS: 25 CAD patients and 27 healthy subjects were selected at random. 24 hours of holter monitoring was performed and plasma NPY levels were measured in all the subjects. RESULTS: Compared with the healthy subjects, SDNN, SDANN, HF and LF in CAD patients significantly decreased, with plasma NPY and LF/HF increased. Plasma NPY levels were closely related to HF, LF and LF/HF. CONCLUSION: Plasma NPY is closely related to HRV in CAD patients.

参考文献/References

[1] 刘润梅, 张志寿, 佟万仁. 神经肽Y与冠心病的关系 [J] . 心脏杂志, 2000, 12(4):314-315.

[2] 张复生, 闫晓霞. 心率变异性研究发展概况 [J] . 心脏杂志, 2000, 12(2):122-1255.

[3] 谢华, 何国祥, 胡亚琴. 冠心病心电图心肌缺血与心率变异性的关系 [J] . 心电学杂志, 1998, 17(3):137.

[4] Verwaerde P, Senard JM, Mazerolles M, et al. Spectral analysis of blood and heart rate catecholamine and neuropeptide y plasm levels in a new model of neuogenic orthostatic hypotension in dog [J] . Clin Auton Res, 1996, 6(2):75-82.

[5] Ullman B, Hulting J, Lundberg JM. Prognostic value of plasma neuropep tide-Y in coronary care unit patients with and without acute myocardial infarction [J] . Eur Heart J, 1994, 15(4):454-461.

[6] 陈灏珠. 心率变异性的测定及其临床意义 [J] . 临床心电学杂志, 1994, 3(4):168-172.

备注/Memo

备注/Memo:
收稿日期：2002-09-24.
更新日期/Last Update: 2003-11-01