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尿激酶对血管升压素诱发的大鼠梗死心肌的保护作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第1期
页码:
37-38
栏目:
实验研究
出版日期:
2004-01-01

文章信息/Info

Title:
The protective action of urine kinase on the myocardial infarction induced by pituitary in rats
作者:
申艳; 刘泽; 李瑜; 王东亚; 贾歌; 刘艳
广州军区广州总医院干部内五科,广东 广州 510010
Author(s):
SHEN Yan;  LIU Ze;  LI Yu;  WANG Dong-ya;  JIA Ge;  LIU Yan
Department of Gerontology, General Hopital of Guangzhu Command of PLA, Guangzhu, Guangong, 510010
关键词:
尿激酶; 垂体后叶素; 大鼠; 心肌酶; 心电描记术
Keywords:
urine kinae;  pituitary;  rat;  myocardial enzymes;  electroardiogram
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的: 探讨尿激酶对血管升压素(Pit)诱发大鼠梗死心肌的保护作用。方法:以SD大鼠腹腔注射Pit(30U/kg)造成心肌梗死模型,观察腹腔注射尿激酶(5万 U/kg)对血清心肌酶(CK、CK-MB、LDH)释放量、心电图 ST段抬高程度以及心肌病理损伤程度的影响。结果:Pit组较对照组心肌酶(CK、CK-MB、LDH)释放量以及心肌病理损伤程度均显著增加(P<0.01),ST段显著抬高(P<0.01);Pit+UK组则较 Pit组心肌损伤程度明显减轻(P<0.01),CK、CK-MB、LDH和ST段分别降低 54.2%、54.5%、48.4%和 56.5%(均为P<0.01)。结论:尿激酶对Pit性心肌梗死大鼠的心肌具有明显的保护作用。
Abstract:
AIM: To study the protective action of urine kinae(UK) on the myocardial infarction induced by pituitary(Pit) in rats. METHODS: The model of mycardial infarction was induced by Pit(30 U/kg, ip) in SD rats. On the model the authors observed the influences of UK(5 ten thousand U/kg, ip) on the releae amount of CK, CK-MB and LDH, the elevatory degree of ST segment of ECG and the degree of myocardial damage in pathology. RESULTS: The release amonts of CK, CK-MB and LDH, the elevatory degree of ST segment of ECG and the degree of myocardial damage in pathology increased in the Pit group compared with the control(all P<0.01). The degree of myocard damage in pathology was abated (P<0.01). The release amount of CK, CK-MB and LDH, and the elevatory degree of ST segment of ECG in the Pit+UK group lowered 54.2%,54.5%,48.4% and 56.5% respetively compare with the Pit group(all P<0.01). CONCLUSION: UK has an obvious protetive action on the myocardial infarction induced by pituitary in rats.

参考文献/References

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[2]于严,汤 健,王东炎,等.牛磺酸对大鼠异丙肾上腺素性心肌损伤的保护作用[J].中国病理生理杂志,1991,7(6):566-567.

[3]冯传玉,沈营.不同剂量尿激酶对急性心肌梗死溶栓疗效的研究[J].河南医药信息,1997,5(12):30-32.

[4]朱永福,李仕芬,钟林,等.院前急救与CCU室联合应用rt-PA与尿激酶治疗急性心肌梗死的对比分析[J].中国实用内科杂志,2002,22(4):225-226.

[5]张秋玲,杨勤.丹参心俞穴位注射对急性心肌梗死大鼠的心梗面积的ET-1的影响[J].贵阳中医学院学报,2002,24(2):61-62.

备注/Memo

备注/Memo:
收稿日期：2003-6-2
更新日期/Last Update: 2004-01-01