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|本期目录/Table of Contents|

急性冠脉综合征患者血浆P-选择素的变化及意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第1期
页码:
41-42
栏目:
临床研究
出版日期:
2004-01-01

文章信息/Info

Title:
The relation of plasma P-selectin to acute coronary syndromes
作者:
陈以初1;  孙健2;  廖树森1;  米红1;  刘薇薇1
1.北海市人民医院心内科,广西 北海 536000;2.吉林大学第二医院心内科,吉林 长春 130041
Author(s):
CHEN Yi-chu1;  SUN Jian2;  LIAO Shu-sen1;  MI Hong1;  LIU Wei-wei1
1.Department of Cardiology Beihai People's Hospital, Beihai, Guangxi 536000; 2.Department of Cardiology, Second Hospital of Jilin University, Cangchun, Jilin 130041
关键词:
P-选择素; 急性冠脉综合征; 脂代谢
Keywords:
P-selectin;  acute coronary syndrome;  lipid metabolism
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:探讨P-选择素在急性冠脉综合征(ACS)发生、发展中的作用,以及脂代谢对P-选择素的影响。方法:采用 ELISA法检测 94例ACS患者[其中AMI32例、不稳定型心绞痛(UA)62例]及稳定型心绞痛(SA)18例和健康成人18例的血浆P-选择素水平。同时把P-选择素与血脂结果作相关分析。结果:血浆P-选择素在AMI、UA、SA和正常组的水平分别为 19.3±5.0、15.3±5.2、11.1±4.3和 10.1±3.5g/L, ACS组的P-选择素高于SA组和正常组(P<0.05)。而在ACS患者中,AMI组的P-选择素又高于UA组(P<0.05)。血脂结果在4组间比较均无显著性差异,但相关分析显示,LDL-c与P-选择素呈正相关(r=0.36,P=0.028)。结论:P-选择素与ACS的发生有关,其水平可反映 ACS的严重性;LDL-c参与血小板的激活。
Abstract:
AIM: To eplore the effect of P-selectin on the pathogenesis and the development of acute coronary syndiomes(ACS), and the influence of lipid metabolism on the plasma P-selectin. METHODS: We measured the level of plasma P-selectin of 94 patients with ACS, 18 with stable angina(SA),18apparently healthy adults with ELISA. Then the correlations of P-selectin to TG、TC、LDL-c、HDL-c were analyzed. RESULTS: The plasma levels of P-selectin were higher in AMI group and unstable angina(UA) group than in SA group and control group(19.3±5.0 and 15.3±5.5g/L vs 11.1±4.3 and 10.1±3.5 g/L, P<0.05). Among the patients with ACS, the plasma P-selectin level of AMI group was higher than that of UA group(P<0.05). No significant differences of lipid levels in each group were found(P>0.05), but there was a positive correlation between the LDL-c and the P-selectin level(r=0.36,P=0.028). CONCLUSION: The study suggest P-selectin is associated with the pathogenesis of ACS and reflect the severity of ACS、LDL-c involves the activtion of platelets.

参考文献/References

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[3]李家增,贺石林,王鸿利,等.血栓病学[M].北京:科学出版社,1998.117.

[4]陈浩,李源,王晓明.可溶性P-选择素与急性冠状动脉综合征的关联性[J].心脏杂志,2003,15(4):326-330.

[5]Murphy RT,Foley JB,Mulvihill N,et al. Impact of preexisting statin use on adhesion molecule epression in patients presenting with acute coronary syndromes[J]. Am J Cardiol,2001,87:446-447.

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备注/Memo

备注/Memo:
收稿日期：2003-3-25
更新日期/Last Update: 2004-01-01