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|本期目录/Table of Contents|

低分子量肝素对高龄不稳定型心绞痛患者凝血、纤溶和抗凝指标的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第2期
页码:
146-148
栏目:
临床研究
出版日期:
2004-03-01

文章信息/Info

Title:
Effect of low molecular weigh the parinon hemostasis, fibrinolysis and anticoagulation systems in treatment of unstable angin apectoris
作者:
刘兆英; 魏延津
临沂市人民医院心内科,山东 临沂 276002
Author(s):
LIU Zhao-ying; WEI Yan-jin
Department of Cardiology, People's Hospital of Linyi, Linyi, Shandong 276002
关键词:
低分子量肝素; 不稳定型心绞痛
Keywords:
low molecular weigh theparin;  unstable angina pectoris
分类号:
R541.2
DOI:
-
文献标识码:
A
摘要:
目的:考察低分子量肝素(LMWH)对高龄不稳定型心绞痛(UAP)患者凝血、纤溶和抗凝指标的影响。方法:UAP患者40例,年龄75～86岁。给予LMWH (Fraciparine, 商品名速避凝) 0.4 ml,腹壁皮下注射,每12h1次,疗程7d。于用药前、末次用药后4h和12h分别抽血测定抗Xa因子活性、血浆凝血酶原时间(PT)、活化部分凝血活酶时间(aPTT)、血浆D-二聚体(D-Dimor)、血浆组织型纤溶酶原激活物(tPA)活性、血浆纤溶酶原激活物抑制物(PAI)及抗凝血酶Ⅲ(AT-Ⅲ)活性。结果:用药后PT、aPTT轻度延长;血浆抗Xa活性及tPA水平增高(P<0.05);D-Dimer含量在LMWH注射后显著降低(P<0.05)。结论:LMWH治疗高龄UAP,皮下注射,每12h1次,可以获得持续的抗血栓效果,可考虑不需要实验室监测。
Abstract:
AIM:To assess the influence on hemostasis, fibrinolysis and anticoa gulation systoms of low molecular weight heparin(LMWH), intreatment of unstable angina pectoris(UAP). METHODS: 40 patients aged 80 years with UAP were treated with LMWH (fraxiparine) ubcutaneous in injection once every 12h for 7days. The plasma PT,aPTT,AXa,D-Dimer, tPA, PAI and AT-Ⅲ were detected before thet reatment and 4h,12h after the last single subcutaneous injection. RESULTS: The laboratory resultss howed that PT,aPTT prolonged slightly (P<0.05), AXa,tPA levels increased (P<0.05) and D-Dimeractivity decteased (P<0.05) after treatment. CONCLUSION: LMWH can be used in very elderly patients with UAP effectively and do not require laboratory determination.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2003-4-10
更新日期/Last Update: 2004-03-01