我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

Na+/H+交换体与血管平滑肌细胞增殖(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第2期
页码:
172-174
栏目:
综述
出版日期:
2004-03-01

文章信息/Info

Title:
-
作者:
房晓帏综述; 李玉光审校
汕头大学医学院第一附属医院, 广东 汕头 515041
Author(s):
-
关键词:
Na+/H+交换体; 血管平滑肌; 细胞增殖
Keywords:
-
分类号:
R972
DOI:
-
文献标识码:
A
摘要:
Na+/H+交换体是存在于真核细胞的一种膜蛋白,调节细胞内pH、Na+浓度(pHi、[Na+]i),在血管平滑肌增生性疾病如高血压、血管成形术后等情况下活性增高,通过使细胞内碱化及细胞内Na+ 浓度升高,起促进细胞增殖、减少细胞凋亡作用,从而促进血管平滑肌细胞增殖;多种血管活性因子通过激活Na+/H+交换体引起血管平滑肌细胞增殖,故推测Na+/H+交换体抑制剂在治疗血管平滑肌细胞增生性疾病中有广泛应用前景。
Abstract:
-

参考文献/References

[1]Burckhardt G,DiSole F,Helmle KC.The Na+/H+ exchanger gene family[J]. J Nephrol,2002,15(Suppl 5):S3-S21.

[2]Bianchini I,Pouysségur J.Molecular structure and regulation of vertebrate Na+/H+ exchangers[J]. J Exp Biol, 1994,196(9):337-345.

[3]Wakabayashi S,Fafournoux P,Sardet C,et al.The Na+/H+ antiporter cytoplasmic domainmedates growth factor signals and controls "H+-sensing"[J]. Proc Natl Acad Sci USA,1992,89(6):2424-2428.

[4]Rao GN,Sardet C,Pouysségur J,et al. Differential regulation of Na+/H+ antiporter gene expression in vascular smooth muscle cells by hypertrophic and hyperplastic stimuli[J].J Biol Chem,1990,265(32):19392-19396.

[5]LaPointe MS,Ye M,Moe OW,et al. Na+/H+ antiporter (NHE-1 isoform) inculture dvascular smooth muscle from the spontaneously hypertensive rat[J].Kidney Int,1995,47(1):78-87.

[6]Quinn DA,Du HK,Thompson BT,et al.Amilorideanalogs inhibit chronic hypoxic pulmonary hypertension[J].Am J Respir Crit Care Med, 1998,157(4Pt1):1263-1268.

[7]Dahm KL,Hannan KM,Farrelly CA,e tal.Diabetes-induced vascular hypertrophy is accompanied by activation of Na+-H+ exchange and prevented by Na+-H+ exchange inhibitor[J].Circ Res,2000,87(22):1133-1140.

[8]涂江华,刘立英,张小红,等.Cariporide对高脂血症引起的兔血管内皮功能损伤的保护作用[J].湖南医科大学学报.2002,27(1):13-16.

[9]罗健东,郑平香,陈修.细胞内pH与细胞凋亡[J].生命科学,1997,9(5):218-221.

[10]Gottlieb RA,Nordberg J,Skowronski E,et al.Apoptosis induced in Jurkat cells by severalagents is preceded by intracellular acidification[J].Proc Natl Acad Sci USA, 1996,93(2):654-658.

[11]Yao W, Qian GS, Yang XJ. Roles ofNHE-1 in the proliferation and apoptosis of pulmonary artery smooth muscle cells in rats[J].Chin Med J,2002,115(1):107-109.

[12]Kusuhara M,Takahashi E,Peterson TE,et al.p38 kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+/H+ exchange and ERK1/2[J]. Circ Res,1998,83(8):824-831.

[13]Peiro C,Angulo J,Llergo JL,et al.Angotensin II mediates cell hypertrophy in vascular smooth muscle cultures from hypertensive Ren-2 transgenic rats by an amiloride-and furosemide-sensitive mechanism[J]. Biochem Biophys Res Commun, 1997,240(2):367-371.

[14]TouyzRM, Schiffrin EL. Activation of theN a+-H+ exchanger modulates angio tensinII-stimulated Na+-dependent Mg2+ transportin vascular smooth muscle cells in genetic hypertension[J]. Hypertension, 999,34(3):442-449.

备注/Memo

备注/Memo:
收稿日期：2003-8-1
更新日期/Last Update: 2004-03-01