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载脂蛋白E基因多态性与冠心病相关因素的关联性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第3期
页码:
252-254
栏目:
临床研究
出版日期:
2004-05-01

文章信息/Info

Title:
The relationship between apolipoprotein E polymorphism and risk factors of coronary heart disease
作者:
张莉莉; 吕安林; 王海昌; 贾国良
第四军医大学西京医院心血管内科，陕西 西安 710032
Author(s):
ZHANG Li-li; LV An-lin; WANG Hai-chang; JIA Guo-liang
Department of Cardiovasology，Xijing Hospital，Fourth Military Medical University，Xi'an Shaanxi 710032，China
关键词:
冠状动脉疾病; 载脂蛋白E; 基因多态性; 冠状动脉硬化斑块; 冠状动脉狭窄
Keywords:
coronary heart disease; apolipoprotein E; polymorphism; coronary atherosclerotic plaques; coronary atherosclerotic stenosis
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:研究载脂蛋白E基因多态性与冠心病的相关因素的关联性。方法:测定121例冠心病患者(均经冠脉造影证实)的基因型。基因型的测定采用PCR-RELP方法。冠状动脉狭窄诊断标准按QCA方法确定。患者的血脂水平按常规方法测定。结果:发现5种基因型，分别为E2/2, E2/3, E3/3, E3/4, E4/4。其中，E4等位基因型频率明显增高(P<0.05 )，与E2/2+E2/3比较，E3/3,E 3/4+E4/4基因型的患者冠状动脉多发狭窄比率偏高，狭窄程度偏重(P<0.05 );E3/4+E4/4等位基因型的冠心病携带者发病年龄偏小(P<0.0 5);E3/4+E4/4组基因型的患者总胆固醇及低密度脂蛋白高于其他基因型(P<0. 01)。结论:载脂蛋白E基因多态性与冠心病早发、严重度和血脂水平相关。
Abstract:
AIM:To investigate the relatioship between apolipoprotein E (apoE) polymorphism and risk factors of coronary heart disease (CHD). METHODS:Genes of 121 CHD patients were measured by PCR-RELPs method. Diagnostic stands of CHD were measured by coronary angiography(CAG). The stands of coronary atherosclerotic stenosis were determined by QCA. Serum lipid levels were measured according to routine methods. RESULTS:Five genotypes of apoE E2/2, E2/3, E3/3, E3/4 and E4/4 were detected in this study，among which apoE4 is most frequently found(P<0.05). Compared with the patients with E2/2+E2/3，more patients with E3/3 and E3/4+E4/4 suffered coronary atherosclerotic stenosis with upgraded severity(P<0.05). And the patients with E3/4+E4/4 were younger than other patients (P<0. 05). TC and LDL-C patients with E3/4+E4/4 were higher than those of the other gene groups(P<0. 01).CONCLUSION: apoE gene polmorphism is associatied not only with the occurrence and development of early-onset and severity of CHD but also with plasma lipid.

参考文献/References

[1] 张俊武，王黎明.人染色体DNA的制备[A].吴冠芸，方福德.基因诊断技术及应用[M].北京:北京医科大学中国协和医科大学联合出版社，1992.175-180.

[2] Hixon JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and clevage with HhalⅠ[J].J Lipid Res,1990,31:545-548.

[3] Nestel P,Sinmons L,Barter P,et al. A comparative study of the efficacy of simvastatin and gemfibrozili n combined hyperlipoproteinemia: predictiono f esponse by baseline lipids,apoE genotype,lipoprotein(a) and insulin[J].Athermclerosis,1997,129 :231-239.

[4] Gauley JA Eichner JE, Hardenig A, et al. apoE alleles irequencies in younger(age65-90)women[J].Genet,1994,60:5 09-516.

[5] Van Bockxmeer PM,Mamotte CD. Apolioprotein epsilon 4 homozy gosity in young men with coronary heart disease[J].Lancent, 1992,340:879-880.

[6] Nassar BA,Dunn J,Title LM,et al. Relation of genetic polymorphisms of apolipoprotein E,an giotensinc overtingenzyme, apolipoprotein B-100,and glycoprotein I a and earlyonset coronary artery heart disease[J]. Clin Biochem, 1999. 32:275-285.

备注/Memo

备注/Memo:
收稿日期：2003-12-31
更新日期/Last Update: 2004-05-01