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充血性心力衰竭患者血浆脑钠素浓度与心功能的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第3期
页码:
266-267
栏目:
临床研究
出版日期:
2004-05-01

文章信息/Info

Title:
Correlation between plasma concentration of brain natriuretic peptide and cardiac function in patients with congestive heart failure
作者:
卢飞舟; 赵殷有
解放军第155医院心内科，河南 开封 475003
Author(s):
LU Fei-zhou; ZHAO Dian-you
Department of Cardiology，155 Hospital of PLA, Kaifeng，Henan 475003,China
关键词:
心力衰竭; 充血性; 脑钠素
Keywords:
heart failure; congestive; brain natriuretic peptide
分类号:
R541.61
DOI:
-
文献标识码:
A
摘要:
目的:探讨充血性心力衰竭(CHF)患者血浆脑钠素(BNP)浓度变化与心功能和30 d再住院率的关系。方法:随机选择CHF患者78例进行心功能分级(NYHA分级)，并测定其人院及出院当天血浆BNP浓度，选择20例健康中老年健康体检者作为对照组。结果:CHF组较对照组血浆BNP浓度明显升高，477±244 pmol/L对184±54 pmol/L(P<0.01)，不同心功能分级之间均有显著差异，NYHA I-N级血浆BNP浓度分别为263±56,412±164,770±142 pmol/L(各组间P<0.01). CHF患者33例出院时血浆BNP浓度小于300 pmol/L,30 d再住院率6%;45例出院时血浆BNP浓度大于300p mol/L,30d 再住院率27% (P<0.05).结论:血浆BNP浓度可作为诊断CHF的参考指标，随着心衰的加重，血浆BNP浓度逐渐升高，当血浆BNP浓度降至300 pmol/L以下时，患者30 d 再住院率显著下降。
Abstract:
AIM:To discuss the relations of the concentration of plasma brain natriuretic peptide (BNP) with the severity of congestive heart failure and the rate of 30-day re-admission. METHODS:Plasma BNP concentrations of congestive heart failure were measured immediately after admission and before discharge. The BNP concentrations of the normal controls were measured immediately as examination only. RESULTS:The Plasma BNP concentrations of congestive heart failure were significantly higher than those of the normal controls (477±244 pmol/L vs 184±54 pmol/L，P<0.01 )，and that they also increased according to these verity of congestive heart failure (P<0. 01). The Plasma BNP concentrations of 33 cases of CHF group were under 300 pmol/L, and those of 45 cases were over 300 pmol/L at discharging. The rate of 30-day re-admission was6% and 27% respectively (P<0.05).CONCLUSION:The Plasma BNP concentrations，which increase according to the severity of CHF,may be an index for diagnosing CHF. The rate of 30-day re-admission is significantly lower if the plasma BNP concentrations are under 300 pmol/L at discharging.

参考文献/References

[1] Yoshimura M, Yasue H, Morita E, et al. Hemodynamic, renal, and hormonal esponses to brain natriuretic peptide in fusion in patients with congestive heart failure[J].Circulation,1991,84,1581-1588.

[2] Langenickel T, Pagel l, Hohnel K, et al. Differential regulation of cardiac ANP and BNP mRNA in differents tages of experimental heart failure[J].Am J Physiol Heart Cire Physiol,2000 ,278：H1500-H1506.

[3]臧益民，臧伟进，王晓明.心力衰场的病理生理机制及治疗概述[J]. 心脏杂志，2002,14(5)：417419。

备注/Memo

备注/Memo:
收稿日期：2003-4-12
更新日期/Last Update: 2004-05-01