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|本期目录/Table of Contents|

替米沙坦治疗充血性心力衰竭的临床观察(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第4期
页码:
342-343
栏目:
临床研究
出版日期:
2004-07-01

文章信息/Info

Title:
Efficacy of Telmisartan in treatment of congestive heart failure
作者:
方志高
温州心血管病医院,浙江 温州 325003
Author(s):
FANG Zhi-gao
Wenzhou Cardiovascular Hospital,Wenzhou, Zhejiang 325003, China
关键词:
替来沙坦血管紧张素Ⅱ心力衰竭充血性
Keywords:
Telmisartanangiotensin Ⅱheart failurecongestive
分类号:
R541-61
DOI:
-
文献标识码:
A
摘要:
目的:观察替米沙坦治疗慢性充血性心力衰蝎(CHF)的临床疗效.方法:经强心、利尿、扩血管等治疗,疗效不佳的CHF患者96例口服替米沙坦40-80 mg,每天1次,疗程4周.观察治疗前后血压、心率、左室舒张末内径、左室射血分数以及心功能变化.结果:4周治疗后血压、心率、左室舒张末内径均明显下降(P<0.05).左室射血分数、心排出A、心脏排血指数等各项指标均明显增加(P<0.01),心功能改善,临床总有效率达98%,患者耐受性好.结 论:替米沙坦治疗CHF疗效好。
Abstract:
AIM:To observe the efficacy of Telmisartan in treatment of congestive heart failure. METHODS:96 patient with heart failure,who had unsatisfactory results under conventional digitals,diuretics,vasodilators therapy, were given telmisartan 40-80mg orally once a day for 4 week. the changes of blood pressure (BP),heart rate (HR),left ventricular end diastolic dimension(LVEDd),left ventricular ejection fraction (LVEF),cardiac output (CO),cardiac index (CI) and cardiac function (NYHA) were observed. RESULTS:4 weeks after treatment,BP, HR and LVEDd decreased significantly (P<0. 05);LVEF,CO,and CI increased (P<0. 01),cardiac function (NYHA) improved 1-2 grade. Telmisartan had few adverse effects and patients tolerance was perfect. CONCLUSION :The efficacy of Telmisartan in treatment of congestive heart failure is satisfactory.

参考文献/References

[1] 臧益民,臧伟进,王晓明.心力衰蝎的病理生理机制及治疗报述[J].心脏杂志,2002,14(5):417-419.

[2] 胡俐英,王晋明,李庚山.血管紧张素I受体阻滞剂的临床研究现状[J].国外医学内科分册,2001,28(4):143-146.

[3] Wienen W,Hauelh ,van Meel JCA, et al.pharmacological characterization of the novel nonpeptide angiotensin I receptor antagonist BIBR277[J].Br J Pharmaclo, 1993, 110:245-252.

[4] 陶则伟,黄元伟.心衰学说的发展与防治[J].心血管病学进展,2003 ,24(1):67-69.

[5] 朱平,管月帆,丁汉臣.叙沙坦治疗高血压病逆转左心室肥厚的疗效观察[J].国外医学心血管疾病分册,2000,27(6):356-358.

[6] Tocehi D,Gazdic LP,Berman R,et al. Angiotensin I receptor blockade combined to ACE inhibition improves ventricular dilation and exercise ejection fractionin congestive heart failure[J].JACC,1998,37(2):391-398.

备注/Memo

备注/Memo:
收稿日期:2003-12-18
更新日期/Last Update: 2004-07-01