我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

MN9202 对离体大鼠胸主动脉的舒张作用及其机制(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第5期
页码:
421-422,426
栏目:
基础研究
出版日期:
2004-09-01

文章信息/Info

Title:
Vasorelaxing role of MN9202 in rat thoracic artery in vitro
作者:
朱肖星1; 梅其炳1; 张峰1; 胡玉珍2; 裴建明2; 吕顺艳2; 陈定章3
第四军医大学:1. 基础部药理学教研室,2. 基础部生理学教研室,3. 西京医院超声科,陕西西安710032
Author(s):
ZHU Xiao-xing1; MEI Qi-bing1; ZHANG Feng1; HU Yu-zhen2; PEI Jian-ming2; Lv Shuen-yan2; CHEN Ding-zhang3
1. Department of Pharmacology ,2. Department of Physiology ,Faculty of Preclinical Medicine , 3. Department of Ultrasound ,Xijing Hospital ,Fourth Military Medical University ,X‘i an ,Shaanxi 710032 ,China
关键词:
MN9202 ; 大鼠; 胸主动脉; 舒张作用; 机制:氯化四乙铵(TEA)
Keywords:
MN9202 ;  rat ;  thoracic arteries ;  vasorelaxing effect ;  mechanism;  tetraethylammonium chloride(TEA)
分类号:
R544. 1 ;R972. 4
DOI:
-
文献标识码:
A
摘要:
目的:研究新合成的二氢吡啶类钙拮抗剂2 ,6-二甲基-4-(3-硝基苯基)-1 ,4-二氢-3 ,5-吡啶二羧酸-3-甲酯-5-正 戊酯(MN9202) 对离体大鼠胸主动脉的舒张作用及其机制。方法:采用离体血管灌流的方法,观察MN9202 对内皮完 整和去内皮胸主动脉的舒张作用,以及TEA(四乙铵) 对这一过程的影响。结果:MN9202 可引起剂量依赖性的舒张 血管效应且无内皮依赖性;钙激活钾通道(KCa) 的阻断剂TEA(10 - 5mol/ L) 可减弱(但不完全阻断) MN9202 舒张血管 的作用,使量效曲线右移。结论:MN9202 对胸主动脉具有不依赖内皮的舒张作用,此作用是通过阻断L-型钙通道 的钙内流,本研究也证明MN9202 舒张胸主动脉作用可能还与KCa有关。
Abstract:
AIM:To investigate the effects and mechanism of methyl penty1 ,4-dihydro-2 ,6-dimethyl-4-(3-ni- trophenyl)-3 ,5-pridinedicarboxylate (MN9202 , a novel dihydropyidine calcium channel blocker) on blood vessel rings of rat thoracic arteries. METHODS :Effects of MN9202 on the tension of vascular strips were observed by n vitro perfusion. The effects of TEA were also observed. RESULTS :It was found that MN9202 caused a concentration-dependent relaxation in rat thoracic arteries which was independent of the endothelium. TEA(10 25mol/ L) , an antagonist of calcium activated potassium channel ( KCa ) reduced but not completely blocked the vasorelaxing effect of MN9202. CONCLUSION: These findings suggest that MN9202 can relax rat thoracic arteries and the vasorelaxing effect of MN9202 is associated with KCa .

参考文献/References

[1 ]甘　戈,贾　敏,梅其炳,等. MN9202 对兔小肠缺血/ 再灌注损伤时血管内皮细胞功能的保护作用[J ] . 第四军医大学学报,1998 ,19 (5) :571 - 573.

[2 ] 王莉莉,李志超, 梅其炳, 等. MN9202 保护血栓大鼠尾动脉血管作用[J ] . 第四军医大学学报,2000 ,21(2) :214 - 216.

[3 ] Lenasi H , Kohlstedt K , Fichtlscherer B , et al . Amlodipine activates the endothelial nitric oxide synthase by altering phosphorylation on Ser1177 and Thr495[J ] . Cardiovas Res ,2003 , 59 : 844 - 853.

[4 ] Francesco C ,Elena V , Chiara L , et al . Electrochemical evidence that lacidipine stimulates release of nitrogen monoxide in rat aorta[J ] . Neuro2 science Letters , 2001 ,298 (3) :171 - 174.

[5 ]弥　曼, 袁秉祥,胡玉珍,等. MN9202 降压作用的实验研究[J ] .心脏杂志,2003 ,15(4) :296 - 299.

[6 ]赖小刚,周士胜. 离子通道与血管张力. 朱妙章,袁文俊,吴博威,等. 心血管生理学与临床[M] . 北京:高等教育出版社,2004. 282- 287.

[7 ]于　军,朱妙章,韦耿泽,等. 血管钠肽对离体人乳内动脉的舒张作用[J ] . 生理学报,2003 ,55(2) :187 - 190.

[8 ]Patterson AJ , Henrie2Olson J , Brenner R. Vasoregulation at the molecular level :a role for theβ1 subunit of the calcium2activated potassium (BK)channel [J ] . TCM ,2002 ,12 :78 - 82.

[9 ]郑永芳,王国勇. 细胞膜钙通道和钾通道[A] . 韩启德,文允镒.血管生物学[M] . 北京:北京医科大学中国协和医科大学联合出版社,1997. 50 - 64.

备注/Memo

备注/Memo:
收稿日期：2003-7-8
更新日期/Last Update: 2004-09-01