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冠心病患者血清C 反应蛋白水平的变化及其临床意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第5期
页码:
443-445
栏目:
临床研究
出版日期:
2004-09-01

文章信息/Info

Title:
The expression and clinic signif icance of serums C-reactive protein in patients with coronary heart disease
作者:
徐彤彤1; 于　方2
1. 桂林医学院附属医院心血管内科, 广西桂林541001 ; 2. 同济医学院附属同济医院, 湖北武汉430030
Author(s):
XU Tong-tong1; YU Fang2
1. Department of Cardiology , Hospital Affiliated Gui LingMedical College , Guiling , Guangxi 541001 , China
关键词:
冠状动脉疾病;  C 反应蛋白
Keywords:
coronary disease ;  C-reactive protein
分类号:
R543. 3
DOI:
-
文献标识码:
A
摘要:
目的: 探讨冠心病(CHD) 患者血清C 反应蛋白(CRP) 水平的变化规律及其临床意义。方法: 采用速率散射比 浊度法定量动态检测100 例不同类型的CHD 患者血清的CRP 水平,同期检测30 例健康志愿者血清的CRP 水平做 对照,并结合临床资料分析。结果:CHD 组CRP 含量明显高于正常对照组( P < 0. 01) ;不同类型的CHD 患者中CRP 浓度,急性心肌梗死(AMI) 组> 不稳定型心绞痛组(UAP) > 稳定型心绞痛(SAP) ,差异有显著性(均P < 0. 01) 。其 动态变化规律是SAP 患者CRP 呈轻度升高,心肌酶谱各指标无显著变化;UAP 组发病早期CRP 升高显著、稳定期下 降迅速,心肌酶谱各指标轻度升高;AMI 组持续升高,心肌酶谱显著升高。结论: CRP 同CHD 关系密切,可作为判 断CHD 危险度的一个有用指标。
Abstract:
AIM: To explore the expression and clinic significance of serums C2reactive protein (CRP) in patients with coronary heart disease (CHD) . METHODS : The level of serum CRP in 100 patients with various CHD were measured and compared with those in 30 healthy controls. RESULTS : The levels of CRP were significantly higher in CHD group than those in healthy group ( P < 0. 01) , and were significantly higher in acute myocard infarction (AMI) group than those in other CHD cases ( P < 0. 01 , respectively) . The levels of CRP、CPK、LDH、α-HAD、AST in stable angina pectoris group didn′t significantly increase compared with health control group ; the level of CRP but not CPK、LDH、α-HAD、AST in unstable angina pectoris group were significantly increased , and the levels of CRP、CPK、LDH、α-HAD、AST were greatly increased in AMI group. CONCLUSION: The level of serum CRP is associated with CHD , CRP may be an independent risk factor for CHD.

参考文献/References

[1 ] 赵季红,侯允天,张利华. 冠心病与炎症的关系以及C 反应蛋白的临床意义[J ] . 心脏杂志,2001 ,13(5) :398 - 400.

[2 ] Blake PM, Rifai N , Clearfield M, et al . Measurement of C-reactive protein and other inflammatory risk markers in acute coronary syndromes[J ] . J Am Coll Cardiol , 2003 , 41 :37 - 42.

[3 ] Ridker PM, Rifai N , Clearfield M, et al . Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events[J ] . N Engl J Med , 2001 , 344 : 1959 - 1965.

[ 4 ] Ridker PM, Stampfer MJ , Rifai N. Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein , fibrinogen , homocysteine , lipoprotein(a) , and standard cholesterol screening as predictors of peripheral arterial disease [J ] . JAMA , 2001 ,285 :2481 - 2485.

[5 ] 张利华,赵季红,薛玉生,等. C 反应蛋白与冠心病病变程度相关的研究[J ] . 心脏杂志,2002 ,14(1) :25 - 26.

[6 ] 王兴祥,周利龙,冯义柏,等. C 反应蛋白与冠状动脉病变的相关性及临床意义[J ] . 心脏杂志,2002 ,14(6) :485 - 487.

备注/Memo

备注/Memo:
收稿日期：2003-12-26
更新日期/Last Update: 2004-09-01