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幽门螺杆菌感染与冠心病发病的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第5期
页码:
454-456
栏目:
临床研究
出版日期:
2004-09-01

文章信息/Info

Title:
Relation between helicobacter pylori infection and coronary heart disease
作者:
王守东;  郭新贵;  林宪如
青岛市市立医院,山东青岛266011
Author(s):
WANG Shou-dong ;  GUO Xin-gui ;  LIN Xian-ru
Department of Cardiology ,Qingdao Municipal Hospital , Qingdao , Shandong 266011 ,China
关键词:
幽门螺杆菌; 感染; 冠状动脉疾病; 危险因素; 内皮素
Keywords:
helicobacter pylori ;  infection ;  coronary disease ;  risk factors ;  endothelin
分类号:
R541. 4
DOI:
-
文献标识码:
A
摘要:
目的: 探讨幽门螺杆菌(Helicobacter pylori ,HP) 感染与冠心病的关系,进一步了解HP 感染在冠心病发病中的 作用。方法: 应用14C 尿素呼气试验对冠心病组(101 例) 和非冠心病组(53 例) 进行测定;应用ELISA 法测定血清HP 抗体(HPIgG) , 确证慢性HP 感染;分别应用ELISA 法及放射免疫法测定冠心病组IL-6 及内皮素-1 (ET-1) 。结果: ① 冠心病组血清HPIgG阳性率显著高于非冠心病组(46 % vs 28 % , P < 0. 05) ; ②冠心病组14C 尿素呼气试验阳性率显 著高于非冠心病组(54 %vs 30 % , P < 0. 01) ; ③冠心病组慢性HP 感染者血浆ET-1 水平显著高于非HP 感染者( P < 0. 05) ; ④现症HP 感染与糖尿病及空腹血糖升高有关( P < 0. 05) 。结论: HP 慢性感染与冠心病有关。HP 慢性感 染者血浆内皮素水平显著升高。
Abstract:
AIM: To investigate the relation of Helicobacter pylori (HP) infection and coronary heart disease (CHD) . METHODS: HPIgG and interleukin-6 (ELISA) were measured and Carbon-14 urea breath test was performed in a total of 101 CHD cases and 53 healthy subjects , and endothelin-1 (RIA) was measured in 53 healthy subjects. RESULTS : ①The rate of seropositive and HPIgGin CHD patients was significantly higher than that of the controls (46 % vs 28 % , P < 0. 05) . ② The positive rate for Carbon214 urea breath test in CHD patients was significantly higher than that of the controls(54 % vs 30 % , P < 0. 01) . ③ For the CHD cases ,the level of plasma endothelin-1 in these of seropositive HPIgGwas higher than that of the patients with seronegative HP( P < 0. 05) . ④For the cases of positive Carbon-14 urea breath test in CHD patients , the level of plasma GLU was higher than that of those with negative Carbon214 urea breath test ( P < 0. 05) . CONCLUSION: Chronic HP infection may be associated with CHD.

参考文献/References

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[5 ] Hoffmeister A , Rothenbacher D , Bode G, et al . Current infection with Helicobacter pylori ,but not seropositivity to chlamydia pneumoniae or cytomegalovirus ,is associated with an atherogenic ,modified lipid profile.Arterioscler[J ] . Thromb Vasc Biol ,2001 ,21(3) :427 - 432.

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备注/Memo

备注/Memo:
收稿日期：2003-10-29
更新日期/Last Update: 2004-09-01