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|本期目录/Table of Contents|

转录因子与心脏发育(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第5期
页码:
480-481,484
栏目:
综述
出版日期:
2004-09-01

文章信息/Info

Title:
-
作者:
林先和;  李隆贵
第三军医大学新桥医院心内科, 重庆400037
Author(s):
-
关键词:
转录因子; 心脏
Keywords:
-
分类号:
Q418
DOI:
-
文献标识码:
A
摘要:
细胞核转录因子是信号联级调节基因转录的最后环节。许多核转录因子与心脏发育有关。Sp ,GATA ,MEF22 和Nkx2. 5 转录因子在胚胎早期心脏的形成及心肌分化的多个环节进行调节,MEF22 还与心脏的病理生理有关。
Abstract:
-

参考文献/References

[1 ] Sachinidis A , Fleischmann BK, Kolossov E , et al . Cardiac specific differentiation of mouse embryonic stem cells[J ] . Cardiovasc Res , 2003 ,58(2) :278 - 291.

[2 ] Suske G. The Sp - family of transcription factors[J ] . Gene , 1999 ,238(2) :291 - 300.

[3 ] Flesch M. On the trail of cardiac specific transcription factors[J ] . Cardiovasc Res , 2001 ,50 (1) :3 - 6.

[4 ] Charron F , Nemer M. GATA transcription factord and cardiac development [J ] . Cell Dev Biol , 1999 ,10 (1) :85 - 91.

[ 5 ] Moore ML , Wang GL , Belaguli NS , et al . GATA-4 and serum response factor regulate transcription of the muscle-specific carnitin palmitoyl-transferase Iβin rat heart [J ] . J Biol Chem , 2001 ,276 (2) : 1026 -1033.

[6 ] Reiter JF , Verkade H , Stainier DYR. Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5[J ] . Dev Biol ,2001 , 234 (2) :330 - 338.

[7 ] Patient RK, McGhee JD. The GATA family (vertebrates and invertebrates) [J ] . Curr Opin Gene Dev , 2002 , 12 (4) :416 - 422.

[8 ] Morin S , Charron F , Robitaille L , et al . GATA2dependent recruitment of MEF1 proteins to target promoters [J ] . EMBO J , 2000 ,19 (9) :2046- 2055.

[9 ] Kolodziejczyk SM, Wang L , Balazsi K, et al . MEF-2 is upregulated during cardiac hypertrophy and is required for normal postnatal growth of the myocardium[J ] . Curr Biol , 1999 ,9 (20) : 1203 - 1206.

[ 10 ] Lin Q , Schwarz J , Bucana C , et al . Control of mouse cardiac morphogenesis and myogenssis by transcription factor MEF-2C[ J ] . Science ,1997 , 276 ; 1404 - 1407.

[11 ] Evans SM. Vertebrate tinman homologues and cardiac differentiation [J ] . Cell Biol , 1999 ,10 (1) :73 - 83.

[12 ]Jamali M, Rogerson PJ , Wilton S , et al . Nkx2 - 5 Activity Is Essential for Cardiomyogenesis [ J ] . J Bio Chem , 2001 , 276 ( 45) : 42252 -42258.

备注/Memo

备注/Memo:
收稿日期：2003-11-20
更新日期/Last Update: 2004-09-01