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增龄对健康犬心房、肺静脉电生理特性的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第6期
页码:
542-544,549
栏目:
基础研究
出版日期:
2004-11-01

文章信息/Info

Title:
Age-related effects on electrophysiological properties of atrium and pulmonary vein in normal canine
作者:
杜新平; 卢才义; 张　健; 侯允天; 王士雯
解放军总医院老年心血管病研究所, 北京100853
Author(s):
DU Xin-ping ;  LU Cai-yi ;  ZHANG Jian ;  HOU Yun-tian ;  WANG Shi-wen
IGC of PLA Hospital , Beijing 100853 ,China
关键词:
肺静脉; 增龄; 心房纤颤; 不应期
Keywords:
Pulmonary vein ;  Aging ;  At rial fibrillation ;  Ref ractory period
分类号:
R331. 38
DOI:
-
文献标识码:
A
摘要:
目的:探讨犬肺静脉(PV) 、心房电生理特性随年龄变化特点。方法:健康杂种犬15 只按年龄分成3 个阶段组:老、中、幼龄组,每组5 只。经锁骨下、股静脉穿刺和房间隔穿刺放置导管,采用刺激诱发心房纤颤(AF) ,标测肺静脉PV、上腔静脉(SVC) 、左、右心房电位,测量各自有效不应期( ERP) 、功能不应期( FRP) ,传导时间。结果:3 组AF 诱发率分别为幼龄组0 %、中龄组20 %、老龄组100 %;起源于PV 的AF 占83. 3 % ,其它为16. 7 %; ERP :老龄犬PV 的ERP 显著短于幼龄组,为132 ±38 ms vs 234 ±51 ms( P < 0. 01) ,老龄组的PV 的ERP 显著短于心房的ERP ,为132 ±38 ms vs 200 ±34 ms( P < 0. 05) ;老龄犬组SVC 的ERP 显著短于幼龄组( P < 0. 05) 。老、中、幼3 组PV 起搏部位发生递减性传导百分率分别为89 %、33 %、31 % ,传导时间延长分别为92 ±55 ms、27 ±31 ms、22 ±38 ms ,老龄组与后两者比较均有非常显著差异( P < 0. 01) 。结论: PV 电生理特点随年龄变化, 电重构集中发生在老龄阶段,主要表现为不应期显著缩短和递减性传导,可能是PV 致AF 的主要原因。
Abstract:
AIM: To investigate the variations in at rium and pulmonary veins with aging. METHODS :15 dogs were allocated to three groups : the old , the middle aged , and the pup , with five dogs in each group. Catheters were int roduced percutaneously through the femoral and jugular veins in all the 15 dogs. A t ransseptal catheterization was performed under fluoroscopic guidance for int roducing circum-ferential mapping and stimulating catheters dedicated to PV mapping. The ERP ,FRP ,and duration of conduction was determined at each elect rode site by the ext rastimulus technique with a programmable stimulator . RESULTS :The rates of AF occurrence were 0 %for the pup , 20 %for the middle aged and 100 %for the old , with 83. 3 % resulting f rom PV and 16. 7 % f rom other sources. The ERP of PV was 132 ±38 ms in the old dogs and 234 ±51 ms in the pup dogs ( P < 0. 01) . In old dogs , the ERP of PV was ignificantly shorter than that of the at rium (132 ±38 ms vs 200 ±34 ms , P < 0. 05) , and ERP of SVC was shorter than in pup dogs ( P < 0. 05) . In PV , decremental conduction occurred (89 % in old dogs vs 33 % in middle age dogs , P < 0. 01 ; 89 % in old dogs vs 31 % in the pup , P < 0. 01) ,and increment of conduction time : 92 ±55 ms in old dogs vs 27 ±31 ms or 22 ±38 ms in the other two groups , P < 0. 01. CONCLUSION: Elect ro-remodeling of PV which occurs f requently at old age may be the main source of AF , with the presenation of significantly short ERP and increment of conduction time.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2004-1-4
更新日期/Last Update: 2004-11-01