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冠心病患者血尿酸水平与细胞因子水平和心功能分级的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第1期
页码:
61-63
栏目:
临床研究
出版日期:
2005-01-05

文章信息/Info

Title:
The correlation between blood uric acid with cytokines and cardiac functional grading in patients with coronary heart disease
作者:
刘松岩1; 杨欣国2; 马岩萍1
1.武警新疆总队医院急诊科，新疆 乌鲁木齐 830091；2.第四军医大学唐都医院心内科，陕西 西安 710038
Author(s):
LIU Songyan1;  YANG Xinguo2;  MA Yanping1
1.Department of Emergency， Xinjiang Municipal Corps Hospital, Chinese People's Armed Police Forces, Ulumuqi，Xinjiang 830091, China
关键词:
冠状动脉疾病;  心功能不全;  尿酸;  细胞因子
Keywords:
coronary disease;  cardiac inadequacy;  blood uric acid;  cytokine
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨冠心病心功能不全患者血尿酸（UA）与细胞因子变化及其与心功能分级的关系。方法 将97例CHD心功能不全患者根据NYHA心功能分级标准分成3个组：Ⅱ级组32例；Ⅲ级组33例；Ⅳ级组32例。采用双抗体夹心DABELISA法检测外周血TNFα、IL1β、IL6水平，采用TOSHIBA7060型自动生化分析仪测定血清尿酸的浓度。结果 不同心功能级别的冠心病患者血清尿酸水平均显著高于对照组(P<0.01)。Ⅲ、Ⅳ级组血清TNFα值显著高于对照组及Ⅱ级组(均P<0.05)。Ⅳ级组血清IL1β水平显著高于各亚组(P<0.05、P<0.01)。Ⅲ、Ⅳ级组血清IL6水平均显著高于对照组(P<0.05)。血尿酸水平与细胞因子TNFα、IL1β、IL6均呈正相关(r=0.28~0.31， P<0.01；r=0.28~0.36， P<0.01；r=0.21~0.33， P<0.01)。 同时血尿酸水平与NYHA心功能分级有相依变动的规律(r=0.48， P<0.01；r=0.53， P<0.01；r=0.61， P<0.01)。结论 冠心病心功能不全患者外周血尿酸水平与细胞因子水平相关，与心衰程度成正相关。
Abstract:
AIM To investigate the correlation between blood uric acid (UA) and cytokines including tumor necrosis factor α(TNFα), interleukine1β(IL1β) and interleukine6 (IL6) in cardiac inadequacy patients with coronary heart disease(CHD). METHODS 97 cardiac inadequacy patients were divided into three groups according to the diovascular functional classes of cardiovascular tunctional classes of New York Heart Association (NYHA) criteria : Class Ⅱgroup, 32 subjects; Class III group, 33 subjects and Class Ⅳgroup, 32 subjects. Serum cytokines in the patients were detected by enzyme linked immune absorption assay (ELISA), and blood uric acid levels were detected by TOSHIBA7060 model automatic biochemistry analyzer. RESULTS The UA levels in the cardiac inadequacy patients were significantly higher than those of the control group (P<0.01), and with the aggravation of heart failure, the UA levels increased greatly. Serum TNFα levels in Class Ⅲ and Class Ⅳ groups were significantly higher than those of the Class Ⅱgroup and the control group (P<0.05, P<0.05); serum IL1β level in Class Ⅳ group was significantly higher than thos of the other subgroups (P<0.05, P<0.01) ； serum IL6 levels in Class Ⅲ and Class Ⅳ groups significantly higher than those of the control group (P<0.05). It showed the linear correlation between the UA were and the cytokines levels including TNFα, IL1βand IL6 (r=0.28~0.31 P<0.01;r=0.28~0.36, P<0.01;r=0.21~0.33, P<0.01) . It also showed the positive correlation between changes in the UA level and the cardiovascular functional class in different groups (r=0.48, P<0.01,r=0.53, P<0.01,r=0.61, P<0.01).CONCLUSIONS UA levels were linearly correlated with the cytokine levels and positively correlated with heart failure degree.

参考文献/References

［1］ Ross R. Atherosclerosis an inflammatory disease［J］. N Engl J Med, 1999,340:115-126.

［2］ Matsumura T, Tsushima K, Ohtaki E, et al. Effects of carvedilol on plasma levels of interleukin6 and tumor necrosis factoralpha in nine patients with dilated cardiomyopathy［J］. J Cardiol, 2002, 39:253-257.

［3］ TorreAmione G, Kapadia S, Benedict C, et al. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVE) ［J］. J Am Coll Cardiol, 1996, 27: 1201-1205.

［4］ Cockerill GW, Huehns TY, Weerasinghe A, et al. Elevation of plasma highdensity lipoprotein concentration reduces interleukin1 induced expression of Eselectin in an in vivo model of acute inflammation［J］. Circulation, 2001,103:108-112.

［5］ Lindmark E, Diderholm E, Wallentin L, et al. Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease, effects of an early invasive or noninvasive strategy［J］. JAMA, 2001, 286:2107-2113.

［6］ Fang Jing, Michael H, Alderman. Serum uric acid and cardiovascular mortality: The NHANES I Epidemiologic Followup Study, 19711992［J］. JAMA, 2000,283:2404-2410.

［7］ Leyva F, Anker SD, Swan JW, et al. Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure［J］. Eur Heart J, 1997,18: 858 - 865.

［8］ 陆丕能,胡大一,陆均金. 冠心病与血尿酸的关系［J］. 中华内科杂志,2002,41:526-529.

［9］ Olexa P, Olexova M, Gonsorcik J, et al. Uric acid a marker for systemic inflammatory response in patients with congestive heart failure?［J］. Wien Klin Wochenschr, 2002,114:211-215.

备注/Memo

备注/Memo:
收稿日期：2004-03-06.
更新日期/Last Update: 2010-01-05