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钙通道阻滞剂MN9202对家兔血流动力学的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第2期
页码:
106-108
栏目:
基础研究
出版日期:
2005-03-05

文章信息/Info

Title:
Effects of calcium channel blocker MN9201 on hemodynamics of rabbits
作者:
弥曼1胡玉珍2张庆红2朱肖星3赵玉峰2梅其炳3
1.陕西省高等医学专科学校药理教研室,陕西 西安 710068; 2.第四军医大学生理学教研室 ;3.第四军医大学药理学教研室, 陕西 西安 710032
Author(s):
MI Man1 HU Yuzhen2 ZHANG Qinghong 2 ZHU Xiaoxing3 ZHAO Yufeng2 MEI Qibing3
1.Department of Pharmacology, Shaanxi Medical College, Xi’an, Shaanxi 710068, China; 2.Department of Phsiology, 3.Department of Pharmacology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China
关键词:
二氢吡啶MN9102钙通道阻滞剂血流动力学
Keywords:
dihydropyridines methyl pentyl 14dihydro26dimethy l4(3nitrophenyl)35 pyridinedicer boxylate (MN9202) Calcium channel blockers hemodynamics
分类号:
R973.2;R972.4
DOI:
-
文献标识码:
A
摘要:
目的 观察新的二氢吡啶类钙拮抗剂2,6二甲基1,4(3硝基苯基)1,4二氢3,5吡啶二羧酸3甲酯5正戊酯(MN9202)对家兔血流动力学的影响。方法 家兔经乌拉坦氯醛糖混合麻药麻醉,进行左心室、股动脉和下腔静脉插管,同时开胸用电磁流量计测定主动脉根部血流量作为心排出量指标。采用计算机联机实时分析方法,观察MN9202的血流动力学效应。结果 间隔10 min,按累积剂量方法分别静脉注射MN9202 1、5、10 μg/kg ,随着给药剂量的增加,动物的血压、总外周阻力显著下降,与此同时,心排出量(CO)显著增加,心脏泵血功能改善,具有明显的剂量依赖关系。结论 MN9202具有显著的的血流动力学效应,不仅作用强,而且持续时间长。
Abstract:
AIM To study the hemodynamic effects of a novel dihydropyidine calcium channel blocker, methyl pentyl 1,4dihydro2,6dimethy l, 4(3nitrophenyl)3,5pyridenedicarboxylate (MN9202), on anaesthetic rabbits. METHODS Rabbits were anaesthetized with sodium pentobarbitone. Three polyethylene catheters were inserted into the left ventricular cavity, femoral artery and inferior vena cava, respectively. Blood flow of aortic artery was detected by electricmagnetic flowmeter. Hemodynamic indexes of anaesthetic rabbits were collected and the effects of MN 9202 were analyzed by an affiliated computer in real time. RESULTS MN9202 was given in an accumulated doses of 1,5 and 10 μg/kg at 10 min intervals. MN9202 exerted significant hemodynamic effects in a dosedependent manner. With an increasing size of MN9202 dosage, blood preasure and total peripheral resistance of rabbits declined. In the meantime, cardiac output was increased, affecting the improvement of heart function. CONCLUSION MN9202 has strong and prolonged effects on the hemodynamic indexes of the rabbits.

参考文献/References

[1] 弥曼,袁秉祥,胡玉珍, 等. MN9202降压作用的实验研究[J]. 心脏杂志, 2003,15(4):296-299.

[2]王莉莉, 裴其应, 梅其炳, 等. MN 9202抗角叉菜胶引起的大鼠血栓形成作用及其对血液流变学的影响[J]. 中国药理学通报,1997,13(6):512-514.

[3]王莉莉,梅其炳,赵德化.2,6二甲基4(3硝基苯基)1,4二氢3,5吡啶二羧酸-3甲酯5戊酯(MN9202) 抗实验性血栓形成作用[J].中国药学杂志, 1998,33(5):282-295.

[4]Wang LL,Mei QB,Zhao DH,et al. Effects of MN9202 on platelet aggregation, 5HT release, TXB2 synthesis, and calcium mobilization in rabbit platelets in vitro[J]. Acta Pharmacol Sin, 2000,21(7):623-626.

[5]王莉莉,梅其炳,赵德化,等.MN9202对血栓形成大鼠红细胞Ca2+浓度、脂质过氧化的影响及其增强红细胞变形性关系的探讨[J].中国药理学通报, 2000,16(4):406-408.

[6] 甘戈, 贾敏, 梅其炳, 等. MN9202对兔小肠缺血再灌注损伤时血管内皮细胞功能的保护作用[J]. 第四军医大学学报, 1998,19(5):571-573.

[7] 甘戈,梅其炳,赵德化.2,6二甲基4(3硝基苯基)1,4二氢3,5吡啶二羧酸3甲酯5戊酯对兔小肠缺血/再灌注损伤所致休克的保护作用[J].中国药理学与毒理学杂志, 1997,11(3):190-193.

[8] 张伟, 梅其炳,陶静仪. 药物血流动力学效应的联机实时测定[J]. 第四军医大学学报,1990,11(增刊2):19-22.

备注/Memo

备注/Memo:
收稿日期:2003-12-27.基金项目:国家科委医药技术创新博士项目(94B04)及陕西省卫生厅青年科研基金(97Q025)
更新日期/Last Update: 2010-01-05