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|本期目录/Table of Contents|

介入技术建立心肌梗死猪动物模型(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第4期
页码:
334-336
栏目:
基础研究
出版日期:
2005-09-05

文章信息/Info

Title:
Establishment of the porcine model of myocardial infarction by interventional technique
作者:
李虎贾国良王海昌郭文怡李伟杰秦涛
第四军医大学西京医院心血管内科, 陕西 西安 710033
Author(s):
LI Hu JIA Guoliang WANG Haichang GUO Wenyi LI Weijie QIN Tao
Department of Cardiology, Xijing hospital, Fourth Military Medical University,Xi′an, Shaanxi 710033, China
关键词:
疾病模型 动物心肌梗死血管造影
Keywords:
disease models animal myocardial infarction angiography
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
目的 建立基于介入技术的猪心肌梗死模型。方法 家猪18只,3~4月龄,体质量50~65 kg, 戊巴比妥钠麻醉后以球囊导管推送海绵颗粒至冠状动脉左前降支远端,造成冠状动脉左前降支远端闭塞。结果 17只猪成功建立心肌梗死模型,1只死亡。10只存活时间大于3个月,6只术后8周按计划处死,1只术后第二天处死,无意外死亡。结论 以球囊导管推送海绵颗粒栓塞冠状动脉建立猪心肌梗死模型,方法简便易行,动物可长期存活。
Abstract:
AIM To establish the porcine model of myocardial infarction by interventional technique. METHODS Eighteen pigs aged 3~4 months and weighing 50~65 kg were anaesthetized. Left anterior descending coronary arteries were embolized by sterilized sponge. RESULTS The model of myocardial infarction was successfully in established in seventeen of the eighteen pigs . Ten of the seventeen survived more than 3 months after myocardial infarction. Six were executed 8 weeks after myocardial infarction. One was executed the next day after myocardial infarction. There were no accidental deaths. CONCLUSION The method of establishing the porcine model of myocardial infarction by interventional technique is simple, convenient and safe.

参考文献/References

[1] Wang QD, Li XS, Lundberg JM, et al. Protective effects of nonpeptide endothelin receptor antagonist bosentan on myocardial ischemic and reperfusion injury in the pig [J]. Cardiovasc Res,1995,29:805-812.

[2] 李醒三,曾志羽,易忠,等. 急性心梗逆行冠状静脉灌注猪动物模型制作[J]. 广西医科大学学报,1999,16:828-829.

[3]肖践明,张敏,王中明,等. 猪心肌梗死模型的建立[J].云南医药,2001,22:82-84.

[4]卢新政,王连生,黄峻,等. 冠状动脉堵闭法建立猪心肌梗死模型[J]. 中国动脉硬化杂志,2004,16:115-118.

[5]赵志敬,贾国良,郭文怡,等. 正常猪及急性心肌梗死猪的左心室电机械标测[J].实用放射学杂志,2004,20: 289-292.

备注/Memo

备注/Memo:
收稿日期:2004-11-09.基金项目:陕西社发公关基金,编号2004K14G6(1)
更新日期/Last Update: 2010-01-05